FTO: a critical role in obesity and obesity-related diseases

被引：8

作者：

Yin, Dan ^{[1
]}

Li, Yiyang ^{[1
]}

Liao, Xingyue ^{[1
]}

Tian, Dewei ^{[1
]}

Xu, Yunsi ^{[1
]}

Zhou, Cuilan ^{[1
]}

Liu, Jun ^{[1
]}

Li, Suyun ^{[1
]}

Zhou, Jing ^{[2
]}

Nie, Yulin ^{[2
]}

Liao, Hongqing ^{[2
]}

Peng, Cuiying ^{[1
]}

机构：

[1] Univ South China, Inst Cytol & Genet, Dept Cell Biol & Genet, Sch Basic Med Sci,Hengyang Med Sch,Dept Educ,Key L, Hengyang 421001, Hunan, Peoples R China

[2] Univ South China, Affiliated Hosp 2, Dept Obstet & Gynecol, 30 Jiefang Rd, Hengyang 421001, Hunan, Peoples R China

来源：

BRITISH JOURNAL OF NUTRITION | 2023年 / 130卷 / 10期

关键词：

FTO; SNP; Obesity; PCOS; Cancer; Type 2 diabetes mellitus; POLYCYSTIC-OVARY-SYNDROME; TYPE-2; DIABETES-MELLITUS; FAT MASS; GENE FTO; RS9939609; POLYMORPHISM; BREAST-CANCER; ASSOCIATION; RNA; VARIANT; WOMEN;

D O I：

10.1017/S0007114523000764

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In recent years, obesity is a growing pandemic in the world and has likely contributed to increasing the incidence of obesity-related diseases. Fat mass and obesity-associated gene (FTO) is the first gene discovered which has a close connection with fat. Recent studies suggested that FTO gene has played an important role in the molecular mechanisms of many diseases. Obesity is considered to be a hereditary disease and can evoke many kinds of diseases, including polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), cancer, etc., whose exact possible molecular mechanisms responsible for the effect of FTO on obesity and obesity-related diseases remain largely unknown. In this review, we comprehensively discuss the correlation between FTO gene and obesity, cancer, PCOS, T2DM, as well as the molecular mechanism involved in these diseases.

引用

页码：1657 / 1664

页数：8

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