The criminal status of prostitution has received greater attention from policymakers and advocates in recent years, but systematic policy change has yet to take root in the United States. These efforts have been both motivated and challenged by a strong moral discourse, resulting in policies that are more reflective of ideology than efficacy. While the popularization of sex work through online avenues like social media has altered the traditional concept of sex work, there is an incomplete understanding of public attitudes toward decriminalization in this modern market. Using national data from 519 U.S. adults, the present study applied Moral Foundations Theory to investigate support for sex work decriminalization in three venues (brothel, online, street). Overall, results show lower support for decriminalization of street sex work compared to brothel and online sex work, and that the effects of moral foundations on support for decriminalization are consistent across all venues. Individualizing foundations (i.e. harm, fairness) do not predict support for decriminalization, while binding and liberty foundations explain some variation in support. Implications of the findings speak to the potential barriers to criminal justice reform in this area and the role of moral arguments in this dispute.