Discovery of Ursolic Acid Derivatives as Inhibitors of Protein Tyrosine Phosphatase 1B

被引：0

作者：

Bai, Xueqian ^{[1
]}

Liu, Zhe ^{[1
]}

Gao, Jing ^{[1
]}

Huang, Bingzhe ^{[1
]}

Zhang, Tianyi ^{[1
]}

机构：

[1] Jilin Med Univ, Jilin 132013, Jilin, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2023年 / 59卷 / 05期

关键词：

ursolic acid; PTP1B enzyme inhibitors; molecular docking;

D O I：

10.1007/s10600-023-04135-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Here, a series of ursolic acid (UA) derivatives were identified as potential protein tyrosine phosphatase 1B (PTP1B) enzyme inhibitors. All of the tested compounds showed potent PTP1B inhibitory activity (47.01-67.89%). Compound 2d (67.89%) exhibited the highest activity of all the synthesized compounds, which showed higher activity than observed for the positive control UA (51.13%). Molecular docking simulation and analysis suggested that compound 2d has a good binding interaction with the active pocket.

引用

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页码：859 / 861

页数：3

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