Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals

被引：31
|
作者：
Gong, Zhaoyuan [1 ]
Bilgel, Murat [2 ]
Kiely, Matthew [1 ]
Triebswetter, Curtis [1 ]
Ferrucci, Luigi [3 ]
Resnick, Susan M. [2 ]
Spencer, Richard G. [4 ]
Bouhrara, Mustapha [1 ,5 ]
机构：
[1] NIA, Magnet Resonance Phys Aging & Dementia MRPAD Unit, NIH, Baltimore, MD USA
[2] NIA, Brain Aging & Behav Sect, NIH, Baltimore, MD USA
[3] NIA, Longitudinal Studies Sect, NIH, Baltimore, MD USA
[4] NIA, Magnet Resonance Imaging & Spect Sect, NIH, Baltimore, MD USA
[5] NIA, Magnet Resonance Phys Aging & Dementia MRPAD Unit, NIH, Baltimore, MD 21224 USA
来源：
ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 07期
基金：
美国国家卫生研究院;
关键词：
cognition; longitudinal analysis; MRI; myelin; HUMAN BRAIN; EXECUTIVE FUNCTION; WATER FRACTION; MATTER DAMAGE; SUPPORT; MODEL; TIME;
D O I：
10.1002/alz.12968
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
IntroductionThe influence of myelination on longitudinal changes in cognitive performance remains unclear. MethodsFor each participant (N = 123), longitudinal cognitive scores were calculated. Myelin content was probed using myelin water fraction (MWF) or longitudinal relaxation rate (R-1); both are MRI measures sensitive to myelin, with MWF being specific. ResultsLower MWF was associated with steeper declines in executive function (p < .02 in all regions) and lower R-1 was associated with steeper declines in verbal fluency (p < .03 in all regions). Additionally, lower R-1 was associated with steeper declines in executive function (p < .02 in all regions) and memory (p < .04 in occipital and cerebral white matter) but did not survive Bonferroni correction. DiscussionWe demonstrate significant relationships between myelin content and the rates of change in cognitive performance among cognitively normal individuals. These findings highlight the importance of myelin in cognitive functioning and suggest MWF and R-1 as imaging biomarkers to predict cognitive changes.
引用
收藏
页码：3098 / 3107
页数：10
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