Biginelli Reaction in the Synthesis of Ethyl 4-(6-Aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates

被引：1
|
作者：
Gein, V. L. [1 ]
Zamaraeva, T. M. [1 ]
Gorgopina, E. V. [1 ]
Dmitriev, M. V. [2 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
[2] Perm State Natl Res Univ, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 01期
关键词：
Biginelli reaction; ethyl 4-(2; 4-dioxo-4-phenylbutanamido)benzoate; arylaldehydes; thiourea; sodium acetate;
D O I：
10.1134/S1070363223010036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three-component Biginelli reaction of ethyl 4-(2,4-dioxo-4-phenylbutanamido)benzoate, aromatic aldehyde and thiourea in acetic acid in the presence of sodium acetate led to the formation of ethyl 4-(6-aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates. Structure of the obtained compounds was established by IR, H-1 NMR, C-13 spectroscopy methods.
引用
收藏
页码：16 / 21
页数：6
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