Sub-MIC levels of bedaquiline and clofazimine can select Mycobacterium tuberculosis mutants with increased MIC

被引：0

作者：

Villellas, Cristina ^{[1
]}

Stevenaert, Frederik ^{[1
,2
]}

Remmerie, Bart ^{[1
]}

Andries, Koen ^{[1
]}

机构：

[1] Janssen Res & Dev, Beerse, Belgium

[2] Aelin Therapeut, Leuven, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2024年 / 68卷 / 04期

关键词：

bedaquiline; tuberculosis; drug resistance; clofazimine; Rv0678; DRUG-RESISTANT TUBERCULOSIS; PHARMACOKINETICS;

D O I：

10.1128/aac.01275-23

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Multidrug-resistant tuberculosis (MDR-TB) patients not cured at the time of stopping treatment are exposed to Minimum Inhibitory Concentration (MIC) and sub-MIC levels for many months after discontinuing bedaquiline (BDQ) or clofazimine (CFZ) treatment. In vitro cultures treated with BDQ and CFZ sub-MIC concentrations clearly showed enrichment in the Rv0678 mutant population, demonstrating that pre-existing Rv0678 mutants can be selected by sub-MIC concentrations of BDQ and CFZ if not protected by an alternative MDR-TB treatment.

引用

页数：4

共 22 条

[21] Sub-MIC levels of purpurin inhibit membrane ATPase-mediated proton efflux activity in the human fungal pathogen Candida albicans
Paul Wai-Kei Tsang
Alan Pak-Kin Wong
Han-Sung Jung
Wing-Ping Fong
[J]. The Journal of Antibiotics, 2014, 67 : 349 - 350
[22] Single-cell electro-phenotyping for rapid assessment of Clostridium difficile heterogeneity under vancomycin treatment at sub-MIC (minimum inhibitory concentration) levels
Rohani, Ali
Moore, John H.
Su, Yi-Hsuan
Stagnaro, Victoria
Warren, Cirle
Swami, Nathan S.
[J]. SENSORS AND ACTUATORS B-CHEMICAL, 2018, 276 : 472 - 480

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