Multinational prospective cohort study over 18 years of the risk factors for ventilator-associated pneumonia in 9 Asian countries: INICC findings

被引：1

作者：

Rosenthal, Victor Daniel ^{[1
,2
,15
]}

Yin, Ruijie ^{[1
]}

Rodrigues, Camilla ^{[3
]}

Myatra, Sheila Nainan ^{[4
]}

Divatia, Jigeeshu Vasishth ^{[4
]}

Biswas, Sanjay K. ^{[4
]}

Shrivastava, Anjana Mahesh ^{[4
]}

Kharbanda, Mohit ^{[5
]}

Nag, Bikas ^{[5
]}

Mehta, Yatin ^{[6
]}

Sarma, Smita ^{[6
]}

Todi, Subhash Kumar ^{[7
]}

Bhattacharyya, Mahuya ^{[7
]}

Bhakta, Arpita ^{[8
]}

Gan, Chin Seng ^{[8
]}

Low, Michelle Siu Yee ^{[8
]}

Kushairi, Marissa Bt Madzlan ^{[8
]}

Chuah, Soo Lin ^{[8
]}

Wang, Qi Yuee ^{[8
]}

Chawla, Rajesh ^{[9
]}

Jain, Aakanksha Chawla ^{[9
]}

Kansal, Sudha ^{[9
]}

Bali, Roseleen Kaur ^{[9
]}

Arjun, Rajalakshmi ^{[10
]}

Davaadagva, Narangarav ^{[9
]}

Bat-Erdene, Batsuren ^{[10
]}

Begzjav, Tsolmon ^{[10
]}

Basri, Mat Nor Mohd ^{[11
]}

Tai, Chian-Wern ^{[11
]}

Lee, Pei-Chuen ^{[11
]}

Tang, Swee-Fong ^{[12
]}

Sandhu, Kavita ^{[13
]}

Badyal, Binesh ^{[13
]}

Arora, Ankush ^{[13
]}

Sengupta, Deep ^{[13
]}

Tao, Lili ^{[14
]}

Jin, Zhilin ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, Miami, FL USA

[2] Int Nosocomial Infect Control Consortium INICC Fdn, Miami, FL USA

[3] Pd Hinduja Natl Hosp & Med Res Ctr, Dept Microbiol, Mumbai, India

[4] Tata Mem Hosp, Homi Bhabha Natl Inst, Dept Anesthesiol Crit Care & Pain, Mumbai, India

[5] Desun Hosp, Dept Crit Care, Kolkata, India

[6] Medanta Medicity, Dept Crit Care & Anesthesiol, Gurgaon, Haryana, India

[7] AMRI Hosp, Adv Medicare Res Inst, Dept Crit Care, Kolkata, India

[8] Univ Malaya, Med Ctr, Dept Pediat Intens Care, Kuala Lumpur, Malaysia

[9] Indraprastha Apollo Hosp, Dept Crit Care, New Delhi, India

[10] Kerala Inst Med Sci Hlth, Dept Crit Care, Trivandrum, India

[11] Int Islamic Univ Malaysia, Dept Anesthesia & Crit Care, Kuantan Pahang, Malaysia

[12] Univ Kebangsaan Malaysia, Specialist Childrens Hosp, Dept Crit Care, Kuala Lumpur, Malaysia

[13] Max Super Special Hosp Saket Delhi, Dept Crit Care, New Delhi, India

[14] Fudan Univ, Zhongshan Hosp, Dept Pneumonol, Shanghai, Peoples R China

[15] Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, 1120 NW 14th St 9th Floor,Off 912, Miami, FL 33136 USA

来源：

AMERICAN JOURNAL OF INFECTION CONTROL | 2023年 / 51卷 / 07期

关键词：

Intensive care unit; Nosocomial pneumonia; Low and middle income countries; Limited resources countries; International nosocomial infection control consortium; INTENSIVE-CARE UNITS; CONTROL CONSORTIUM INICC; DEVICE-ASSOCIATED INFECTIONS; MULTIDIMENSIONAL APPROACH; NOSOCOMIAL INFECTIONS; SOCIOECONOMIC IMPACT; ADULT; PREVENTION; CITIES; RATES;

D O I：

10.1016/j.ajic.2022.11.005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Ventilator associated pneumonia (VAP) rates in Asia are several times above those of US. The objective of this study is to identify VAP risk factors. Methods: We conducted a prospective cohort study, between March 27, 2004 and November 2, 2022, in 279 ICUs of 95 hospitals in 44 cities in 9 Asian countries (China, India, Malaysia, Mongolia, Nepal, Pakistan, Philippines, Sri Lanka, Thailand, Vietnam). Results: 153,717 patients, followed during 892,996 patient-days, acquired 3,369 VAPs. We analyzed 10 independent variables. Using multiple logistic regression we identified following independent VAP RFs= Age, rising VAP risk 1% per year (aOR=1.01; 95%CI=1.00-1.01, P<.0001); male gender (OR=1.17; 95%CI=1.08-1.26, P<.0001); length of stay, rising VAP risk 7% daily (aOR=1.07; 95%CI=1.06-1.07, P<.0001); mechanical ventilation (MV) device utilization (DU) ratio (OR=1.43; 95%CI=1.36-1.51; p<.0001); tracheostomy connected to a MV (OR=11.17; 95%CI=9.55-14.27; p<.0001); public (OR=1.84; 95%CI=1.49-2.26, P<.0001), and private (OR=1.57; 95%CI=1.29-1.91, P<.0001) compared with teaching hospitals; upper-middle income country (OR=1.86; 95%CI=1.63-2.14, P<.0001). Regarding ICUs, Medical-Surgical (OR=4.61; 95%CI=3.43-6.17; P<.0001), Neurologic (OR=3.76; 95%CI=2.43-5.82; P<.0001), Medical (OR=2.78; 95%CI=2.04-3.79; P<.0001), and Neuro-Surgical (OR=2.33; 95%CI=1.61-3.92; P<.0001) showed the highest risk. Conclusions: Some identified VAP RFs are unlikely to change= age, gender, ICU type, facility ownership, country income level. Based on our results, we recommend limit use of tracheostomy, reducing LOS, reducing the MV/DU ratio, and implementing an evidence-based set of VAP prevention recommendations. (c) 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

引用

页码：751 / 757

页数：7

共 50 条

[31] Multicenter prospective study of ventilator-associated pneumonia during acute respiratory distress syndrome -: Incidence, prognosis, and risk factors
Markowicz, P
Wolff, M
Djedaïni, K
Cohen, Y
Chastre, J
Delclaux, C
Merrer, J
Herman, B
Veber, B
Fontaine, A
Dreyfuss, D
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (06) : 1942 - 1948
[32] Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study
Jean-Francois Timsit
Carole Schwebel
Lenka Styfalova
Muriel Cornet
Philippe Poirier
Christiane Forrestier
Stéphane Ruckly
Marie-Christine Jacob
Bertrand Souweine
Intensive Care Medicine, 2019, 45 : 834 - 843
[33] Impact of bronchial colonization with Candida spp. on the risk of bacterial ventilator-associated pneumonia in the ICU: the FUNGIBACT prospective cohort study
Timsit, Jean-Francois
Schwebel, Carole
Styfalova, Lenka
Cornet, Muriel
Poirier, Philippe
Forrestier, Christiane
Ruckly, Stephane
Jacob, Marie-Christine
Souweine, Bertrand
INTENSIVE CARE MEDICINE, 2019, 45 (06) : 834 - 843
[34] Incidence and predictors of ventilator-associated pneumonia using a competing risk analysis: a single-center prospective cohort study in Egypt
Elsheikh, Mohamed
Kuriyama, Akira
Goto, Yoshihito
Takahashi, Yoshimitsu
Toyama, Mayumi
Nishikawa, Yoshitaka
El Heniedy, Mohamed Ahmed
Abdelraouf, Yasser Mohamed
Okada, Hiroshi
Nakayama, Takeo
BMC INFECTIOUS DISEASES, 2024, 24 (01)
[35] Multinational Prospective Cohort Study of Mortality Risk Factors in 198 ICUs of 12 Latin American Countries over 24 Years: The Effects of Healthcare-Associated Infections
Rosenthal, Victor Daniel
Yin, Ruijie
Liliana Valderrama-Beltran, Sandra
Milena Gualtero, Sandra
Yaneth Linares, Claudia
Aguirre-Avalos, Guadalupe
Cesar Mijangos-Mendez, Julio
Angel Ibarra-Estrada, Miguel
Fernanda Jimenez-Alvarez, Luisa
Patricia Reyes, Lidia
Arturo Alvarez-Moreno, Carlos
Adelia Zuniga-Chavarria, Maria
Marcela Quesada-Mora, Ana
Gomez, Katherine
Alarcon, Johana
Millan Onate, Jose
Aguilar-De-Moros, Daisy
Castano-Guerra, Elizabeth
Cordoba, Judith
Sassoe-Gonzalez, Alejandro
Marisol Millan-Castillo, Claudia
Leyva Xotlanihua, Lissette
Alejandra Aguilar-Moreno, Lina
Bravo Ojeda, Juan Sebastian
Gutierrez Tobar, Ivan Felipe
Cruz Aleman-Bocanegra, Mary
Veronica Echazarreta-Martinez, Clara
Mireya Flores-Sanchez, Belinda
Andrea Cano-Medina, Yuliana
Giovannny Chapeta-Parada, Edwin
Antonio Gonzalez-Nino, Rafael
Isabel Villegas-Mota, Maria
Montoya-Malvaez, Mildred
Angel Cortes-Vazquez, Miguel
Medeiros, Eduardo Alexandrino
Fram, Dayana
Vieira-Escudero, Daniela
Jin, Zhilin
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH, 2022, 12 (04) : 504 - 515
[36] Multinational Prospective Cohort Study of Mortality Risk Factors in 198 ICUs of 12 Latin American Countries over 24 Years: The Effects of Healthcare-Associated Infections
Victor Daniel Rosenthal
Ruijie Yin
Sandra Liliana Valderrama-Beltran
Sandra Milena Gualtero
Claudia Yaneth Linares
Guadalupe Aguirre-Avalos
Julio Cesar Mijangos-Méndez
Miguel Ángel Ibarra-Estrada
Luisa Fernanda Jimenez-Alvarez
Lidia Patricia Reyes
Carlos Arturo Alvarez-Moreno
Maria Adelia Zuniga-Chavarria
Ana Marcela Quesada-Mora
Katherine Gomez
Johana Alarcon
Jose Millan Oñate
Daisy Aguilar-De-Moros
Elizabeth Castaño-Guerra
Judith Córdoba
Alejandro Sassoe-Gonzalez
Claudia Marisol Millán-Castillo
Lissette Leyva Xotlanihua
Lina Alejandra Aguilar-Moreno
Juan Sebastian Bravo Ojeda
Ivan Felipe Gutierrez Tobar
Mary Cruz Aleman-Bocanegra
Clara Veronica Echazarreta-Martínez
Belinda Mireya Flores-Sánchez
Yuliana Andrea Cano-Medina
Edwin Giovannny Chapeta-Parada
Rafael Antonio Gonzalez-Niño
Maria Isabel Villegas-Mota
Mildred Montoya-Malváez
Miguel Ángel Cortés-Vázquez
Eduardo Alexandrino Medeiros
Dayana Fram
Daniela Vieira-Escudero
Zhilin Jin
Journal of Epidemiology and Global Health, 2022, 12 : 504 - 515
[37] Risk factors for ventilator-associated pneumonia due to Staphylococcus aureus in patients with severe brain injury: A multicentre retrospective cohort study
Launey, Yoann
Asehnoune, Karim
Lasocki, Sigismond
Dahyot-Fizelier, Claire
Huet, Olivier
Le Pabic, Estelle
Malejac, Bastien
Seguin, Philippe
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE, 2021, 40 (01)
[38] An Epidemiological Study on Incidence, Predictors, and Prognosis of Ventilator-associated Pneumonia in Intensive Care Unit: A Prospective Cohort Study in Egypt
Elsheikh, M. M.
Kuriyama, A.
Goto, Y.
Takahashi, Y.
Toyama, M.
Nishikawa, Y.
El Heniedy, M. A.
Abdelraouf, Y. M.
Okada, H.
Nakayama, T.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
[39] Sonographic patterns of lung consolidation in mechanically ventilated patients with and without ventilator-associated pneumonia: A prospective cohort study
Berlet, Thomas
Etter, Reto
Fehr, Tobias
Berger, David
Sendi, Parham
Merz, Tobias M.
JOURNAL OF CRITICAL CARE, 2015, 30 (02) : 327 - 333
[40] Risk Factors for Stroke-associated Pneumonia: A Prospective Cohort Study
Suarez Quesada, Alexis
Lopez Espinosa, Ezequiel
Garcia Verdecia, Noelsis
Serra Valdes, Miguel Angel
FINLAY, 2015, 5 (04): : 242 - 252

← 1 2 3 4 5 →