Microbiota of pregnancy, placenta and newborns in the third trimester: A randomized controlled study

被引:5
|
作者
Li, Zhe [1 ]
Zhang, Yiwen [1 ]
Wang, Li [1 ]
Deng, Tye Kian [2 ]
Chiu, Wei-Hsiu [3 ]
Ming, Wai-kit [4 ]
Xu, Chengfang [1 ]
Xiao, Xiaomin [5 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Obstet, Guangzhou, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 5, Dept Obstet, Guangzhou, Guangdong, Peoples R China
[3] Chung Shan Hosp, Dept Obstet & Gynecol, Taipei, Taiwan
[4] City Univ Hong Kong, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China
[5] Jinan Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China
关键词
Gut microbiota; Vaginal microbiota; Gestational; Placenta; Fetus; GUT MICROBIOTA; BACTERIA;
D O I
10.1016/j.heliyon.2024.e24698
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Microbiota in pregnant time is vital to healthy of pregnant women and their offspring. However, few study evaluate the composition of the microbiota of health pregnancy, placenta and their newborns at different stages and the origin of the placental microbiota. Samples were obtained from a total of 31 pregnant individuals and their offspring, analyzing by 16S rRNA amplicon sequencing of the V4 region to evaluate the composition and variation of them. We found that the microbiota of pregnant individuals changes in the third trimester. The placental microbiota has its own specific dominant microbiota. The placental microbiota is correlated with the pregnancy microbiota in the gut and vagina at 32-34 weeks but not at full term. The gut microbiota in newborns changes over the first 14 days.
引用
收藏
页数:13
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