The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye

被引：1

作者：

Sala, Lorenzo ^{[1
,6
]}

Prud'homme, Christophe ^{[2
]}

Guidoboni, Giovanna ^{[3
]}

Szopos, Marcela ^{[4
]}

Harris, Alon ^{[5
]}

机构：

[1] Univ Paris Saclay, INRAE, MaIAGE, Jouy En Josas, France

[2] Univ Strasbourg, IRMA, Strasbourg, France

[3] Univ Maine, Elect & Comp Engn, Orono, ME USA

[4] Univ Paris Cite, CNRS, MAP5, Paris, France

[5] Icahn Sch Med Mt Sinai, New York, NY USA

[6] Univ Paris Saclay, INRAE Unite MaIAGE, Bat 210, F-78352 Jouy En Josas, France

来源：

INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING | 2024年 / 40卷 / 02期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

hybridizable discontinuous Galerkin method; mathematical and computational ophthalmology; multiphysics and multiscale modeling; ocular hemodynamics and biomechanics; validation; OPTIC-NERVE HEAD; CENTRAL RETINAL ARTERY; OPEN-ANGLE GLAUCOMA; LAMINA-CRIBROSA; INTRAOCULAR-PRESSURE; ELASTIC PROPERTIES; GALERKIN METHOD; BLOOD-PRESSURE; FLOW; DEFORMATION;

D O I：

10.1002/cnm.3791

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present our continuous efforts from a modeling and numerical viewpoint to develop a powerful and flexible mathematical and computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims to solve problems arising in biomechanics and hemodynamics within the human eye. We discuss our contribution towards improving the reliability and reproducibility of computational studies by performing a thorough validation of the numerical predictions against experimental data. The OMVS proved capable of simulating complex multiphysics and multiscale scenarios motivated by the study of glaucoma. Furthermore, its modular design allows the continuous integration of new models and methods as the research moves forward, and supports the utilization of the OMVS as a promising non-invasive clinical investigation tool for personalized research in ophthalmology.

引用

页数：34