Association of Plasma Irisin Levels with Circulating Endothelial Microparticles (EMPs) and Endothelial Progenitor Cells (EPCs) in Children Born Prematurely

被引:3
|
作者
Markopoulou, Panagiota [1 ]
Koutroumpa, Arsinoi [2 ]
Mantzou, Aimilia [3 ]
Margeli, Alexandra [4 ]
Papanikolaou, Eleni [5 ]
Siahanidou, Tania [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pediat 1, Neonatal Unit, Athens 11527, Greece
[2] Agia Sofia Childrens Hosp, Neonatal Intens Care Unit 2, Athens 11527, Greece
[3] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pediat 1, Unit Clin & Translat Res Endocrinol, Athens 11527, Greece
[4] Agia Sofia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece
[5] Natl & Kapodistrian Univ Athens, Sch Med, Lab Biol, Athens 11527, Greece
关键词
prematurity; endothelial dysfunction; endothelial microparticles; endothelial progenitor cells; irisin; children; CARDIOMETABOLIC RISK-FACTORS; PRETERM BIRTH; HEART-FAILURE; DYSFUNCTION; METABOLISM; BIOMARKERS; OBESITY; WEIGHT; MUSCLE;
D O I
10.3390/metabo13010120
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Prematurity has been linked with endothelial dysfunction in later life. The purpose of this study was to evaluate the association between plasma irisin, an adipomyokine reported to protect the functional integrity of vascular endothelium, and circulating endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs), consisting early biomarkers of endothelial dysfunction, in preterm-born children. We studied 131 prepubertal children; 61 preterm and 70 born at term (controls). Plasma irisin was determined by ELISA. Circulating CD62E(+), CD144(+) and CD31(+)/CD42b(-) EMPs, and CD34(+)/VEGFR-2(+)/CD45(-) and CD34(+)/VEGFR-2(+)/CD45dim EPCs, were determined by flow cytometry. Body mass index, waist-to-hip ratio, neck circumference, systolic and diastolic blood pressure, and biochemical parameters (glucose, lipids, insulin, HOMA-IR) were also evaluated. Plasma irisin was significantly lower (p = 0.001), whereas circulating EMPs and EPCs were higher, in children born prematurely compared to controls. Irisin was recognized as independent predictor for CD144(+) and CD31(+)/CD42b(-) EMPs, CD34(+)/VEGFR-2(+)/CD45(-) and CD34(+)/VEGFR-2(+)/CD45dim EPCs in the total study population, and for CD31(+)/CD42b(-) EMPs in the preterm group. In conclusion, plasma irisin correlates independently with circulating EMP and EPC subpopulations in prepubertal children and in preterm-born ones. Further studies in children will potentially elucidate the link between irisin and the primary stages of prematurity-related endothelial dysfunction.
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页数:14
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