A Compact Synthesis and Biological Evaluation of Biginilli Products of 1,3-Bis(3-Chlorophenyl)-2-Thioxodihydropyrimidine-4,6(1H,5H)-Dione

A new series of thiobarbituric acids was designed and the compounds were synthesized by a simple and highly productive Biginelli method. The characterization of the synthesized compounds was done using various spectroscopic methods. All the newly synthesized compounds 8a-l were screened as inhibitors of bacterial strains. The strains of bacteria used were Staphylococcus aureus, MTCC 96; Escherichia coli, MTCC 64; Salmonella typhi; MTCC537; Klebsiella pneumoniae, MTCC 424; Pseudomonas aeruginosa, MTCC 424;Chromobacterium violaceum. The specific impact of compounds on different strains of bacteria was observed and the derivatives were found to possess varying degree of antibacterial activities. It was thus inferred that the activity of the compound was affected by its molecular structure and the type of bacterial strain, it was tested against.