[1] Univ Hosp Sussex NHS Trust, Brighton & Sussex Clin Trials Unit, Brighton, E Sussex, England
[2] Univ Sussex, Dept Med, Brighton & Sussex Med Sch, Brighton, E Sussex, England
[3] Guys & St Thomas NHS Fdn Trust, Royal Brompton & Harefield Cinical Grp, Res Off, London, England
[4] Univ Urbino, Urbino, Italy