Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping

被引:5
|
作者
Kitsak, Maksim [1 ,2 ]
Ganin, Alexander [3 ,4 ]
Elmokashfi, Ahmed [5 ]
Cui, Hongzhu [6 ,7 ]
Eisenberg, Daniel A. [8 ]
Alderson, David L. [8 ]
Korkin, Dmitry [6 ,9 ,10 ]
Linkov, Igor [11 ]
机构
[1] Delft Univ Technol, Fac Elect Engn Math & Comp Sci, NL-2600 GA Delft, Netherlands
[2] Northeastern Univ, Network Sci Inst, 177 Huntington Ave, Boston, MA 02115 USA
[3] Univ Virginia, Dept Syst & Informat Engn, Charlottesville, VA 22904 USA
[4] US Army, Engineer Res & Dev Ctr, Concord, MA 01742 USA
[5] Simula Metropolitan Ctr Digital Engn, Oslo, Norway
[6] Worcester Polytech Inst, Bioinformat & Computat Biol Program, Worcester, MA 01609 USA
[7] Columbia Univ, Inst Genom Med, Med Ctr, New York, NY USA
[8] Naval Postgrad Sch, Dept Operat Res, Monterey, CA 93943 USA
[9] Worcester Polytech Inst, Comp Sci Dept, Worcester, MA 01609 USA
[10] Worcester Polytech Inst, Data Sci Program, Worcester, MA 01609 USA
[11] US Army, Engineer Res & Dev Ctr, Environm Lab, Concord, MA 01742 USA
基金
荷兰研究理事会;
关键词
UBIQUITINATION;
D O I
10.1038/s41467-022-35181-w
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Shortest paths between the nodes of complex networks are challenging to obtain if the information on network structure is incomplete. Here the authors show that the shortest paths are geometrically localized in hyperbolic representations of networks, and can be detected even if the large amount of network links are missing. The authors demonstrate the utility of geometric pathfinding in Internet routing and the reconstruction of cellular pathways. Dynamic processes on networks, be it information transfer in the Internet, contagious spreading in a social network, or neural signaling, take place along shortest or nearly shortest paths. Computing shortest paths is a straightforward task when the network of interest is fully known, and there are a plethora of computational algorithms for this purpose. Unfortunately, our maps of most large networks are substantially incomplete due to either the highly dynamic nature of networks, or high cost of network measurements, or both, rendering traditional path finding methods inefficient. We find that shortest paths in large real networks, such as the network of protein-protein interactions and the Internet at the autonomous system level, are not random but are organized according to latent-geometric rules. If nodes of these networks are mapped to points in latent hyperbolic spaces, shortest paths in them align along geodesic curves connecting endpoint nodes. We find that this alignment is sufficiently strong to allow for the identification of shortest path nodes even in the case of substantially incomplete networks, where numbers of missing links exceed those of observable links. We demonstrate the utility of latent-geometric path finding in problems of cellular pathway reconstruction and communication security.
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页数:9
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