DNA Damage Response Constrains Cell Growth and Drives Clonal Hematopoiesis in Telomere Biology Disorders

被引:2
|
作者
Sande, Christopher M. [1 ]
Chen, Stone [2 ]
Mitchell, Dana V. [3 ]
Lin, Ping [2 ,4 ]
Deolikar, Rujul Jagdish [2 ]
Freeman, Colby [2 ]
Zhou, Mary [2 ]
Kumar, Sushant [2 ]
Zheng, Shannon [2 ]
Munkhbileg, Bolormaa [2 ,4 ]
Stanley, Natasha L. [2 ,5 ]
Guo, Kathy [2 ]
Hausler, Ryan [2 ]
Taylor, Deanne M. [3 ,6 ]
Corines, James [1 ]
Morrissette, Jennifer J. D. [1 ]
Lieberman, David B. [1 ]
Yang, Guang [1 ]
Smith-Simmer, Kelcy [7 ]
Banaszak, Lauren G. [7 ]
Shoger, Kyle [7 ]
Nicholas, Peter [4 ,8 ]
Walne, Amanda J. [9 ]
Dokal, Inderjeet [9 ]
Rosenheck, Justin [10 ]
Churpek, Jane E. [7 ]
Johnson, F. Bradley [1 ]
Olson, Timothy S. [4 ,8 ]
Babushok, Daria V. [2 ,4 ]
机构
[1] Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA
[2] Hosp Univ Penn, Div Hematol Oncol, Dept Med, Philadelphia, PA USA
[3] Childrens Hosp Philadelphia, Dept Biomed & Hlth Informat, Philadelphia, PA USA
[4] Childrens Hosp Philadelphia, Comprehens Bone Marrow Failure Ctr, Philadelphia, PA USA
[5] Childrens Hosp Pennsylvania, Dept Pediat, Philadelphia, PA USA
[6] Hosp Univ Penn, Dept Pediat, Philadelphia, PA USA
[7] Univ Wisconsin Madison, Div Hematol Med Oncol & Palliat Care, Dept Med, Madison, WI USA
[8] Childrens Hosp Philadelphia, Div Oncol, Dept Pediat, Philadelphia, PA USA
[9] Queen Mary Univ London, Blizard Inst, Fac Med & Dent, London, England
[10] Ohio State Univ, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH USA
关键词
D O I
10.1182/blood-2023-173666
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [31] Telomere Shortening Delays DNA Damage Response in Human Cells
    Drissi, R.
    Wu, J.
    Bockhold, C.
    Dome, J.
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2012, 53 : S35 - S35
  • [32] A DNA damage checkpoint response in telomere-initiated senescence
    di Fagagna, FD
    Reaper, PM
    Clay-Farrace, L
    Fiegler, H
    Carr, P
    von Zglinicki, T
    Saretzki, G
    Carter, NP
    Jackson, SP
    NATURE, 2003, 426 (6963) : 194 - 198
  • [33] Clonal hematopoiesis: background player in plasma cell-free DNA variants
    Sun, Kun
    ANNALS OF TRANSLATIONAL MEDICINE, 2019, 7
  • [34] Plasma Circulating Tumor DNA and Clonal Hematopoiesis in Metastatic Renal Cell Carcinoma
    Bacon, Jack V. W.
    Annala, Matti
    Soleimani, Maryam
    Lavoie, Jean-Michel
    So, Alan
    Gleave, Martin E.
    Fazli, Ladan
    Wang, Gang
    Chi, Kim N.
    Kollmannsberger, Christian K.
    Wyatt, Alexander W.
    Nappi, Lucia
    CLINICAL GENITOURINARY CANCER, 2020, 18 (04) : 322 - +
  • [35] IL-1 DRIVES CLONAL HEMATOPOIESIS VIA SELECTIVE INDUCTION OF GROWTH ARREST IN NORMAL HSC
    Pietras, Eric
    Rabe, Jennifer
    Higa, Kelly
    Chavez, James
    Mills, Taylor
    Nemkov, Travis
    Nerlov, Claus
    Dinarello, Charles
    D'Alessandro, Angelo
    DeGregori, James
    EXPERIMENTAL HEMATOLOGY, 2018, 64 : S93 - S93
  • [36] The Telomere Deprotection Response Is Functionally Distinct from the Genomic DNA Damage Response
    Cesare, Anthony J.
    Hayashi, Makoto T.
    Crabbe, Laure
    Karlseder, Jan
    MOLECULAR CELL, 2013, 51 (02) : 141 - 155
  • [37] Rapid induction of telomeric DNA damage response and reduction of clonogenic tumor cell growth by the telomere targeting agent RHPS4
    Phatak, P.
    Stevens, M. F. G.
    Burger, A. M.
    EJC SUPPLEMENTS, 2006, 4 (12): : 188 - 188
  • [38] Clonal medicine targeting DNA damage response eradicates leukemia
    Toma, Monika M.
    Karami, Adam
    Nieborowska-Skorska, Margaret
    Chirtala, Kumaraswamy Naidu
    Pepek, Monika
    Hadzijusufovic, Emir
    Stoklosa, Tomasz
    Valent, Peter
    Skorski, Tomasz
    LEUKEMIA, 2024, 38 (02) : 281 - 290
  • [39] Clonal medicine targeting DNA damage response eradicates leukemia
    Monika M. Toma
    Adam Karami
    Margaret Nieborowska-Skorska
    Kumaraswamy Naidu Chirtala
    Monika Pepek
    Emir Hadzijusufovic
    Tomasz Stoklosa
    Peter Valent
    Tomasz Skorski
    Leukemia, 2024, 38 : 671 - 675
  • [40] Clonal Medicine Targeting DNA Damage Response Eradicates AML
    Toma, Monika
    Karami, Adam
    Nieborowska-Skorska, Margaret
    Chitrala, Kumaraswamy
    Valent, Peter
    Skorski, Tomasz
    BLOOD, 2023, 142