Pulmonary Vascular Remodeling in Pulmonary Hypertension

被引：15

作者：

Jia, Zhuangzhuang ^{[1
,2
]}

Wang, Shuai ^{[1
]}

Yan, Haifeng ^{[3
]}

Cao, Yawen ^{[1
]}

Zhang, Xuan ^{[1
,2
]}

Wang, Lin ^{[1
,2
]}

Zhang, Zeyu ^{[1
,2
]}

Lin, Shanshan ^{[1
,2
]}

Wang, Xianliang ^{[1
]}

Mao, Jingyuan ^{[1
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Teaching Hosp 1, Dept Cardiovasc Dis, Tianjin 300381, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China

[3] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiovasc Dis, Zhengzhou 450000, Peoples R China

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 02期

关键词：

pulmonary hypertension; pulmonary vascular remodeling; intima; media; adventitia; extracellular matrix; SMOOTH-MUSCLE-CELLS; TO-MESENCHYMAL TRANSITION; ARTERIAL-HYPERTENSION; INDUCED PROLIFERATION; CELLULAR MECHANISMS; ENDOTHELIAL-CELLS; INHIBITION; THROMBOMODULIN; TRANSCRIPTION; INFLAMMATION;

D O I：

10.3390/jpm13020366

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia. Pulmonary vascular remodeling consists of the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs) of the middle membranous pulmonary artery, as well as complex interactions involving external layer pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis and other factors in the vascular wall are influenced by different mechanisms that likely act in concert to drive disease progression. This article reviews these pathological changes and highlights some pathogenetic mechanisms involved in the remodeling process.

引用

页数：18

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