Case Report: Two Case Reports of Pulmonary Hypertension after mRNA COVID-19 Vaccination

被引:0
|
作者
Sullivan, Robert D. [1 ]
Shults, Nataliia V. [2 ]
Suzuki, Yuichiro J. [3 ]
机构
[1] US Anesthesia Partners, Frederick, MD 21701 USA
[2] Georgetown Univ, Dept Biol, Washington, DC 20007 USA
[3] Georgetown Univ Med Ctr, Dept Pharmacol & Physiol, Washington, DC 20007 USA
基金
美国国家卫生研究院;
关键词
case report; COVID-19; mRNA; pulmonary hypertension; vaccine; SPIKE PROTEIN; PRESSURE;
D O I
10.3390/diseases11030114
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: We herein report two cases of sudden onset symptomatic pulmonary hypertension after coronavirus disease 2019 (COVID-19) vaccination. Case Summary: Pulmonary hypertension in previously healthy adult males occurred within three weeks of receiving the second dose of the Pfizer (BNT162b2) mRNA COVID-19 vaccine from different lots. Both patients experienced a sudden onset of severe fatigue and dyspnea on exertion with negative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing. The diagnosis was made by serial transthoracic echocardiography in the first case and by both transthoracic echocardiography and right heart catheterization in the second. Both cases resulted in functional limitations and likely permanent organ damage. No evidence of pulmonary emboli was detected in either case. Discussion: Pulmonary hypertension is a serious disease characterized by damage to lung vasculature and restricted blood flow through narrowed arteries from the right to left heart. The onset of symptoms is typically insidious, progressive and incurable, leading to right heart failure and premature death. The World Health Organization (WHO) classifies pulmonary hypertension into five categories and recently re-defined it as a resting mean pulmonary artery pressure greater than 20 mmHg. Sudden onset pulmonary hypertension would only be expected in the settings of surgical pneumonectomy or massive pulmonary emboli with compromise of at least 50% of the lung vasculature. We present here two novel cases of sudden onset pulmonary hypertension without evidence of pulmonary emboli, both of which occurred after receiving a COVID-19 mRNA vaccine.
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页数:7
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