Antigen Delivery Systems: Past, Present, and Future

被引：2
|
作者：
Ko, Hyun-Jeong [1 ]
Kim, Yeon-Jeong [2 ,3 ,4 ]
机构：
[1] Kangwon Natl Univ, Dept Pharm, Lab Microbiol & Immunol, Chunchon 24341, South Korea
[2] Inje Univ, Coll Pharm, Lab Microbiol & Immunol, Gimhae 50834, South Korea
[3] Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, South Korea
[4] Inje Univ, Smart Marine Therapeut Ctr, Gimhae 50834, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2023年 / 31卷 / 04期
关键词：
Vaccine; Antigen delivery system; Vector; Nanoparticle; Self-assembled particles; Extracellular vesicle; T-CELL RESPONSES; OUTER-MEMBRANE VESICLES; GAS-FILLED MICROBUBBLES; VIRUS-LIKE PARTICLES; IMMUNE-RESPONSES; VACCINE DELIVERY; DENDRITIC CELLS; DNA VACCINE; CANCER; IMMUNIZATION;
D O I：
10.4062/biomolther.2023.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The COVID-19 pandemic has increased demand for safe and effective vaccines. Research to develop vaccines against diseases including Middle East respiratory syndrome, Ebolavirus, human immunodeficiency virus, and various cancers would also contribute to global well-being. For successful vaccine development, the advancement of technologies such as antigen (Ag) screening, Ag delivery systems and adjuvants, and manufacturing processes is essential. Ag delivery systems are required not only to deliver a sufficient amount of Ag for vaccination, but also to enhance immune response. In addition, Ag types and their delivery systems determine the manufacturing processes of the vaccine product. Here, we analyze the characteristics of various Ag delivery systems: plasmids, viral vectors, bacterial vectors, nanoparticles, self-assembled particles, natural and artificial cells, and extracellular vesicles. This review provides insight into the current vaccine landscape and highlights promising avenues of research for the development and improvement of Ag delivery systems.
引用
收藏
页码：370 / 387
页数：18
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