The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis

被引：5
|
作者：
Xu, Yahan [1 ,2 ]
Lan, Peixiang [3 ,4 ,5 ,6 ]
Wang, Tao [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Resp & Crit Care Med, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Natl Hlth Comm NHC, Tongji Hosp, Tongji Med Coll,Key Lab Resp Dis, Wuhan 430030, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Organ Transplantat, Tongji Med Coll, Wuhan 430030, Peoples R China
[4] Chinese Acad Med Sci, Minist Educ, Key Lab Organ Transplantat, Wuhan 430030, Peoples R China
[5] Chinese Acad Med Sci, NHC, Key Lab Organ Transplantat, Wuhan 430030, Peoples R China
[6] Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan 430030, Peoples R China
来源：
MEDICINA-LITHUANIA | 2023年 / 59卷 / 11期
基金：
中国国家自然科学基金;
关键词：
idiopathic pulmonary fibrosis; immune cell; macrophage; T cells; DELTA T-CELLS; MAST-CELLS; BRONCHOALVEOLAR LAVAGE; NK CELLS; DENDRITIC CELLS; LUNG FIBROSIS; PIRFENIDONE; MICE; INFLAMMATION; ATTENUATION;
D O I：
10.3390/medicina59111984
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology with limited treatment options. The role of the immune system in IPF has received increasing attention. Uncontrolled immune responses drive the onset and progression of IPF. This article provides an overview of the role of innate immune cells (including macrophages, neutrophils, mast cells, eosinophils, dendritic cells, nature killer cells, nature kill cells and gamma delta T cells) and adaptive immune cells (including Th1 cells, Th2 cells, Th9 cells, Th17 cells, Th22 cells, cytotoxic T cells, B lymphocytes and Treg cells) in IPF. In addition, we review the current status of pharmacological treatments for IPF and new developments in immunotherapy. A deeper comprehension of the immune system's function in IPF may contribute to the development of targeted immunomodulatory therapies that can alter the course of the disease.
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页数：17
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