Mathematical analysis of neurological disorder under fractional order derivative

被引:5
|
作者
Khan, Nadeem [1 ]
Ali, Amjad [1 ]
Ullah, Aman [2 ]
Khan, Zareen A. [3 ]
机构
[1] Univ Engn & Technol, Dept Basic Sci & Islamiat, Peshawar, Pakistan
[2] Univ Malakand, Dept Math, Dir, Khyber Pakhtunk, Pakistan
[3] Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Math Sci, POB 84428, Riyadh 11671, Saudi Arabia
来源
AIMS MATHEMATICS | 2023年 / 8卷 / 08期
关键词
fractional operator; existence theory; numerical method; unique solution; SYSTEM; LYMPHOCYTES; CYTOKINES; ATROPHY; BRAIN;
D O I
10.3934/math.2023959
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
Multiple sclerosis (MS) is a common neurological disorder that affects the central nervous system (CNS) and can cause lesions that spread over space and time. Our study proposes a mathematical model that illustrates the progression of the disease and its likelihood of recurrence. We use Caputo fractional-order (FO) derivative operators to represent non-negative solutions and to establish a steady-state point and basic reproductive number. We also employ functional analysis to prove the existence of unique solutions and use the Ulam-Hyres (UH) notion to demonstrate the stability of the solution for the proposed model. Furthermore, we conduct numerical simulations using an Euler-type numerical technique to validate our theoretical results. Our findings are presented through graphs that depict various behaviors of the model for different parameter values.
引用
收藏
页码:18846 / 18865
页数:20
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