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Mathematical analysis of neurological disorder under fractional order derivative
被引:5
|作者:
Khan, Nadeem
[1
]
Ali, Amjad
[1
]
Ullah, Aman
[2
]
Khan, Zareen A.
[3
]
机构:
[1] Univ Engn & Technol, Dept Basic Sci & Islamiat, Peshawar, Pakistan
[2] Univ Malakand, Dept Math, Dir, Khyber Pakhtunk, Pakistan
[3] Princess Nourah bint Abdulrahman Univ, Coll Sci, Dept Math Sci, POB 84428, Riyadh 11671, Saudi Arabia
来源:
关键词:
fractional operator;
existence theory;
numerical method;
unique solution;
SYSTEM;
LYMPHOCYTES;
CYTOKINES;
ATROPHY;
BRAIN;
D O I:
10.3934/math.2023959
中图分类号:
O29 [应用数学];
学科分类号:
070104 ;
摘要:
Multiple sclerosis (MS) is a common neurological disorder that affects the central nervous system (CNS) and can cause lesions that spread over space and time. Our study proposes a mathematical model that illustrates the progression of the disease and its likelihood of recurrence. We use Caputo fractional-order (FO) derivative operators to represent non-negative solutions and to establish a steady-state point and basic reproductive number. We also employ functional analysis to prove the existence of unique solutions and use the Ulam-Hyres (UH) notion to demonstrate the stability of the solution for the proposed model. Furthermore, we conduct numerical simulations using an Euler-type numerical technique to validate our theoretical results. Our findings are presented through graphs that depict various behaviors of the model for different parameter values.
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页码:18846 / 18865
页数:20
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