Characterization and Anti-Aging Activity of Polysaccharides from Akebia trifoliata Fruit Separated by an Aqueous Two-Phase System

被引：9
|
作者：
Zhang, Zhonghao [1 ]
Gao, Tao [1 ]
Yan, Ningning [1 ]
Duan, Zhihao [1 ]
Tang, Zizhong [1 ]
Zhou, Lijun [1 ]
Chen, Tao [1 ]
Feng, Shiling [1 ]
Ding, Chunbang [1 ]
Yuan, Shu [2 ]
Yuan, Ming [1 ]
机构：
[1] Sichuan Agr Univ, Coll Life Sci, Yaan 625014, Peoples R China
[2] Sichuan Agr Univ, Coll Resources, Chengdu, Peoples R China
来源：
PLANT FOODS FOR HUMAN NUTRITION | 2023年 / 78卷 / 01期
关键词：
Active polysaccharides; Antioxidant activity; Anti-aging; Akebia trifoliata; PHYSICOCHEMICAL PROPERTIES; LIFE-SPAN;
D O I：
10.1007/s11130-022-01031-9
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioactive polysaccharides have numerous pharmacological effects that are beneficial to human health. Akebia trifoliata (Thunb.) Koidz. has great development prospects as a food resource with medicinal value. The polysaccharides (ATFP) were extracted from A. trifoliata fruit by an aqueous two-phase system. ATFP-3, purified with DEAE-52 and Sephadex G-200 from ATFP, was mainly composed of glucose (47.55%) and galactose (20.39%). Its hydroxyl radical scavenging rate was 89.30% at 1.60 mg/mL and its IC50 was 0.29 mg/mL. ATFP-3 significantly enhanced the survival rate of Caenorhabditis elegans under thermal or oxidative stress. Furthermore, ATFP-3 could prolong the lifespan of C. elegans and improve the activities of the antioxidant enzyme, while also decrease the accumulation of lipofuscin and the level of malondialdehyde (MDA) in aging worms. Thus, ATFP-3 has application potential in health benefits for humans.
引用
收藏
页码：154 / 159
页数：6
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