Human leukocyte immunoglobulin-like receptors in health and disease

被引:14
|
作者
Redondo-Garcia, Silvia [1 ]
Barritt, Christopher [1 ,2 ,3 ]
Papagregoriou, Charys [1 ,6 ]
Yeboah, Muchaala [1 ]
Frendeus, Bjorn [1 ,4 ]
Cragg, Mark S. [1 ,5 ]
Roghanian, Ali [1 ,5 ]
机构
[1] Univ Southampton, Sch Canc Sci, Antibody & Vaccine Grp, Ctr Canc Immunol,Fac Med,Southampton Gen Hosp, Southampton, England
[2] Glasgow Royal Infirm, Lister Dept Gen Surg, Glasgow, Scotland
[3] Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Scotland
[4] BioInvent Int AB, Lund, Sweden
[5] Univ Southampton, Inst Life Sci, Southampton, England
[6] Ctr Study Haematol & Other Malignancies, Nicosia, Cyprus
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
LILR; immune tolerance; cancer; autoimmunity; infection; immunomodulation; immunotherapy; MHC CLASS-I; SOLUBLE HLA-G; T-SUPPRESSOR-CELLS; ANTIGEN-PRESENTING CELLS; TOLEROGENIC ENDOTHELIAL-CELLS; PLASMACYTOID DENDRITIC CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYELOID-LEUKEMIA; NATURAL-KILLER-CELLS; VERSUS-HOST-DISEASE;
D O I
10.3389/fimmu.2023.1282874
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) or inhibitory (LILRB) depending on their associated signalling domains (D). With the exception of the soluble LILRA3, LILRAs mediate immune activation, while LILRB1-5 primarily inhibit immune responses and mediate tolerance. Abnormal expression and function of LILRs is associated with a range of pathologies, including immune insufficiency (infection and malignancy) and overt immune responses (autoimmunity and alloresponses), suggesting LILRs may be excellent candidates for targeted immunotherapies. This review will discuss the biology and clinical relevance of this extensive family of immune receptors and will summarise the recent developments in targeting LILRs in disease settings, such as cancer, with an update on the clinical trials investigating the therapeutic targeting of these receptors.
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页数:29
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