Drug Discovery and Development of miRNA-Based Nucleotide Drugs for Gastrointestinal Cancer

被引：3
|
作者：
Sato, Hiromichi [1 ,2 ]
Hara, Tomoaki [1 ]
Meng, Sikun [1 ]
Tsuji, Yoshiko [1 ]
Arao, Yasuko [1 ]
Sasaki, Kazuki [1 ,2 ]
Miyoshi, Norikatsu [2 ]
Kobayashi, Shogo [2 ]
Doki, Yuichiro [2 ]
Eguchi, Hidetoshi [2 ]
Ishii, Hideshi [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Ctr Med Innovat & Translat Res, Dept Med Data Sci, Yamadaoka 2-2, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Dept Gastrointestinal Surg, Yamadaoka 2-2, Suita, Osaka 5650871, Japan
来源：
BIOMEDICINES | 2023年 / 11卷 / 08期
关键词：
epigenetic reprogramming; induced pluripotent stem cells; miRNA-modified nucleotide drugs; gastrointestinal cancers; SQUAMOUS-CELL CARCINOMA; PLURIPOTENT STEM-CELLS; HUMAN HEPATOCELLULAR-CARCINOMA; REPROGRAMMING EFFICIENCY; PROMOTES PROLIFERATION; PROGNOSTIC BIOMARKER; IN-VIVO; DELIVERY; SUPPRESSION; CISPLATIN;
D O I：
10.3390/biomedicines11082235
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Short non-coding RNAs, miRNAs, play roles in the control of cell growth and differentiation in cancer. Reportedly, the introduction of miRNAs could reduce the biologically malignant behavior of cancer cells, suggesting a possible use as therapeutic reagents. Given that the forced expression of several miRNAs, including miR-302, results in the cellular reprograming of human and mouse cells, which is similar to the effects of the transcription factors Oct4, Sox2, Klf4, and c-Myc, this suggests that the selective introduction of several miRNAs will be able to achieve anti-cancer effects at the epigenetic and metabolic levels. In this review article, we bring together the recent advances made in studies of microRNA-based therapeutic approaches to therapy-resistant cancers, especially in gastrointestinal organs.
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页数：13
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