Polymer complexes: LXXX-characterization, DNA cleavage properties, antimicrobial activity and molecular docking studies of transition metal complexes of Schiff base

A new series of polymer complexes of Cu(II), Co(II), Ni(II), Mn(II) and Cd(II) with 4-[(2,4-dihydroxy-benzylidene)-amino]-1,5-dimethyl-2-phenyl-1,2-dihydroxo-pyrazol-3-one (H2L) ligand were prepared and characterized. From the elemental analysis data, the polymer complexes were proposed to have the general formula {[M(L)(OH2)(2)]center dot xH(2)O}(n) where M = Cu(II)(1), x = 1.25; M = Co(II)(2), Ni(II)(3), Mn(II)(4) and Cd(II)(5), x = nil. The molar conductance data revealed that all the polymer complexes were non-electrolytes. The synthesized ligand, in comparison with its metal polymer complexes, was screened for their antibacterial activity against bacterial species. It was found that the metal complexes have more antimicrobial activities than the Schiff base ligand against some microbial species. Some complexes showed higher activity than ligand. The antibacterial activity of Cd(II) complex (5) was the highest ones than the ligand and other complexes as well as penicillin G against Bacillus cereus, Staphylococcus aureus and Pseudomonas sp. The anticandidal activity of Cd(II) complex (5) was the highest ones than the ligand and other complexes as well as miconazole against Candida albicans.