Emerging applications of single-cell profiling in precision medicine of atherosclerosis

被引：1

作者：

Lin, Huiling ^{[1
,2
]}

Zhang, Ming ^{[3
]}

Hu, Mi ^{[1
]}

Zhang, Yangkai ^{[1
]}

Jiang, Weiwei ^{[4
]}

Tang, Wanying ^{[1
]}

Ouyang, Yuxin ^{[1
]}

Jiang, Liping ^{[5
]}

Mi, Yali ^{[3
]}

Chen, Zhi ^{[6
]}

He, Pingping ^{[7
]}

Zhao, Guojun ^{[3
]}

Ouyang, Xinping ^{[1
,2
,8
,9
]}

机构：

[1] Univ South China, Inst Neurosci Res, Med Coll, Dept Physiol,Hengyang Key Lab Neurodegenerat & Cog, Hengyang 421001, Hunan, Peoples R China

[2] Hunan Normal Univ, Sch Med, Dept Physiol, Changsha 410081, Hunan, Peoples R China

[3] Guangzhou Med Univ, Affiliated Qingyuan Hosp, Qingyuan Peoples Hosp, Qingyuan 511518, Guangdong, Peoples R China

[4] Southern Med Univ, Zhujiang Hosp, Dept Organ Transplantat, Guangzhou, Guangdong, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China

[6] Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen, Peoples R China

[7] Hunan Normal Univ, Sch Med, Dept Nursing, Changsha 410081, Hunan, Peoples R China

[8] Hunan Normal Univ, Sch Med, Key Lab Model Anim & Stem Cell Biol Hunan Prov, Changsha 410081, Hunan, Peoples R China

[9] Hunan Normal Univ, Engn Res Ctr Reprod & Translat Med Hunan Prov, Sch Med, Changsha 410081, Hunan, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2024年 / 22卷 / 01期

关键词：

Single-cell sequencing; Precision medicine; Atherosclerosis; Cellular heterogeneity; RED-BLOOD-CELLS; INTRAVASCULAR ULTRASOUND; CORONARY; INFLAMMATION; TECHNOLOGIES; MICROBIOTA; CIRCUITS; STORAGE; COMPLEX; BURDEN;

D O I：

10.1186/s12967-023-04629-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis remains largely incurable. In this review, we discuss emerging single-cell sequencing techniques and their novel insights into atherosclerosis. We provide examples of single-cell profiling studies that reveal phenotypic characteristics of atherosclerosis plaques, blood, liver, and the intestinal tract. Additionally, we highlight the potential clinical applications of single-cell analysis and propose that combining this approach with other techniques can facilitate early diagnosis and treatment, leading to more accurate medical interventions.

引用

页数：14

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