Current and future perspectives of single-cell multi-omics technologies in cardiovascular research

Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic and epigenetic heterogeneity in cardiac disease and development. We then introduce the key concepts in single-cell multi-omics modalities that apply to cardiovascular research. Lastly, we discuss some of the trending concepts in single-cell technology that are expected to propel cardiovascular research to the next phase of single-cell research. Wen Tan et al. review the current technologies available for single-cell transcriptomics, epigenomics and multi-omics analyses, their impact on the cardiovascular research and possible future applications.