Current and future perspectives of single-cell multi-omics technologies in cardiovascular research

被引：3

作者：

Tan, Wilson Lek Wen ^{[1
]}

Seow, Wei Qiang ^{[1
]}

Zhang, Angela ^{[1
,2
]}

Rhee, Siyeon ^{[1
,2
]}

Wong, Wing H. ^{[3
,4
]}

Greenleaf, William J. ^{[5
]}

Wu, Joseph C. ^{[1
,2
,6
]}

机构：

[1] Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[2] Greenstone Biosci, Palo Alto, CA 94304 USA

[3] Stanford Univ, Sch Med, Dept Stat, Stanford, CA USA

[4] Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA USA

[5] Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA

[6] Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA

来源：

NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 01期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTOME ANALYSIS; GENE-EXPRESSION; RNA-SEQ; CHROMATIN ACCESSIBILITY; HUMAN HEART; REVEALS; PROTEINS; HETEROGENEITY; THOUSANDS; PLATFORM;

D O I：

10.1038/s44161-022-00205-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Single-cell technology has become an indispensable tool in cardiovascular research since its first introduction in 2009. Here, we highlight the recent remarkable progress in using single-cell technology to study transcriptomic and epigenetic heterogeneity in cardiac disease and development. We then introduce the key concepts in single-cell multi-omics modalities that apply to cardiovascular research. Lastly, we discuss some of the trending concepts in single-cell technology that are expected to propel cardiovascular research to the next phase of single-cell research. Wen Tan et al. review the current technologies available for single-cell transcriptomics, epigenomics and multi-omics analyses, their impact on the cardiovascular research and possible future applications.

引用

页码：20 / 34

页数：15

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