Construction of a colorimetric sensor array for the identification of phenolic compounds by the laccase-like activity of N-doped manganese oxide

Phenolic compounds, widely distributed in nature, encompass a diverse array of bioactive and antioxidant properties. The detection of different phenolic compound types holds paramount importance in elucidating their bioactivity and health effects, ensuring the quality and safety of food and drugs. Consequently, the development of simple, rapid, and cost-effective colorimetric sensing arrays capable of simultaneous phenolic compound detection has emerged as a prominent research pursuit. In this study, we present a one-step hydrothermal synthesis of N-doped MnO2 nanoflowers (NMF). NMF possess an extensive specific surface area and abundant oxygen vacancies, effectively mimicking the activity of natural laccase. Leveraging this laccase-like activity, NMF demonstrates the ability to catalyze various phenolic compounds, generating distinctive fingerprint signals. Notably, the developed colorimetric sensing array exhibits remarkable efficacy in effectively identifying and differentiating phenolic compounds within complex mixtures. Furthermore, the NMF colorimetric sensing array demonstrates successful identification of phenolic compounds in diverse environments, including food and urine samples. Overall, this study provides new insights into the design of transition metal materials for the simulation of laccase and colorimetric sensing arrays. It provides a promising avenue for the development of advanced detection platforms for phenolic compounds.