Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic

被引:5
|
作者
Spernovasilis, Nikolaos [1 ,2 ,3 ]
Kritsotakis, Evangelos I. [1 ,4 ]
Mathioudaki, Anna [2 ]
Vouidaski, Alexandra [2 ]
Markaki, Ioulia [2 ]
Psaroudaki, Despoina [2 ]
Ioannou, Petros [1 ,2 ]
Kofteridis, Diamantis P. [1 ,2 ]
机构
[1] Univ Crete, Sch Med, Iraklion 71500, Greece
[2] Univ Hosp Heraklion, Dept Internal Med & Infect Dis, Iraklion 71500, Greece
[3] German Oncol Ctr, Dept Infect Dis, CY-4108 Limassol, Cyprus
[4] Univ Crete, Sch Med, Lab Biostat, Iraklion 71500, Greece
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 01期
关键词
point prevalence survey; carbapenems; antimicrobial stewardship; COVID-19;
D O I
10.3390/antibiotics12010039
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Irrational use of antimicrobials poses a significant risk for public health by aggravating antimicrobial resistance. The aim of this repeated point prevalence survey (PPS) was to evaluate the impact of a carbapenem-focused antimicrobial stewardship program (ASP) on overall antimicrobial use and quality of antimicrobial prescribing during the COVID-19 pandemic. Methods: All adult inpatients in the University Hospital of Heraklion in Greece were audited twice, before and after the implementation of the ASP, in October 2019 and October 2020, respectively. Patient characteristics, indications and diagnoses for antimicrobial administration, antimicrobials prescribed, and compliance with treatment guidelines were recorded. Results: Of 743 adult inpatients on the days of the two surveys, 398 (53.6%) were on antimicrobials for 437 diagnoses. Following implementation of the ASP, there was substantial decrease in the utilization of carbapenems (4.9% of all antibacterials prescribed in the second PPS compared to 10.3% in the first PPS). A significant improvement was observed for all indicators of the quality of antimicrobial prescribing. Conclusions: Our study demonstrated a positive impact of an ASP implementation during the first stages of the COVID-19 pandemic on reducing the use of last-line antimicrobials and improving overall quality of antimicrobial prescribing.
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页数:10
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