Antimicrobial Prescribing before and after the Implementation of a Carbapenem-Focused Antimicrobial Stewardship Program in a Greek Tertiary Hospital during the COVID-19 Pandemic

被引:5
|
作者
Spernovasilis, Nikolaos [1 ,2 ,3 ]
Kritsotakis, Evangelos I. [1 ,4 ]
Mathioudaki, Anna [2 ]
Vouidaski, Alexandra [2 ]
Markaki, Ioulia [2 ]
Psaroudaki, Despoina [2 ]
Ioannou, Petros [1 ,2 ]
Kofteridis, Diamantis P. [1 ,2 ]
机构
[1] Univ Crete, Sch Med, Iraklion 71500, Greece
[2] Univ Hosp Heraklion, Dept Internal Med & Infect Dis, Iraklion 71500, Greece
[3] German Oncol Ctr, Dept Infect Dis, CY-4108 Limassol, Cyprus
[4] Univ Crete, Sch Med, Lab Biostat, Iraklion 71500, Greece
来源
ANTIBIOTICS-BASEL | 2023年 / 12卷 / 01期
关键词
point prevalence survey; carbapenems; antimicrobial stewardship; COVID-19;
D O I
10.3390/antibiotics12010039
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Irrational use of antimicrobials poses a significant risk for public health by aggravating antimicrobial resistance. The aim of this repeated point prevalence survey (PPS) was to evaluate the impact of a carbapenem-focused antimicrobial stewardship program (ASP) on overall antimicrobial use and quality of antimicrobial prescribing during the COVID-19 pandemic. Methods: All adult inpatients in the University Hospital of Heraklion in Greece were audited twice, before and after the implementation of the ASP, in October 2019 and October 2020, respectively. Patient characteristics, indications and diagnoses for antimicrobial administration, antimicrobials prescribed, and compliance with treatment guidelines were recorded. Results: Of 743 adult inpatients on the days of the two surveys, 398 (53.6%) were on antimicrobials for 437 diagnoses. Following implementation of the ASP, there was substantial decrease in the utilization of carbapenems (4.9% of all antibacterials prescribed in the second PPS compared to 10.3% in the first PPS). A significant improvement was observed for all indicators of the quality of antimicrobial prescribing. Conclusions: Our study demonstrated a positive impact of an ASP implementation during the first stages of the COVID-19 pandemic on reducing the use of last-line antimicrobials and improving overall quality of antimicrobial prescribing.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Antimicrobial Resistance and Antimicrobial Stewardship: Before, during and after the COVID-19 Pandemic
    Khaznadar, Omar
    Khaznadar, Farah
    Petrovic, Ana
    Kuna, Lucija
    Loncar, Ana
    Omanovic Kolaric, Tea
    Mihaljevic, Vjera
    Tabll, Ashraf A.
    Smolic, Robert
    Smolic, Martina
    [J]. MICROBIOLOGY RESEARCH, 2023, 14 (02) : 727 - 740
  • [2] Antimicrobial stewardship program during the COVID-19 pandemic
    Jorge, Laura
    Lauricella, Maria Cecilia
    Klajn, Diana
    Molina, Ana Maria
    Del Valle, Sofia
    Rodriguez, Viviana M.
    [J]. MEDICINA-BUENOS AIRES, 2022, 82 (05) : 641 - 646
  • [3] Prescribing trends before and after implementation of an antimicrobial stewardship program
    Cairns, Kelly A.
    Jenney, Adam W. J.
    Abbott, Iain J.
    Skinner, Matthew J.
    Doyle, Joseph S.
    Dooley, Michael
    Cheng, Allen C.
    [J]. MEDICAL JOURNAL OF AUSTRALIA, 2013, 198 (05) : 262 - 266
  • [4] Prescribing patterns of carbapenem and the acceptance of a carbapenem antimicrobial stewardship program in a tertiary teaching hospital in Malaysia
    Ong, H. -C.
    Teo, S. W.
    Goh, S. S. L.
    Tan, C. H.
    Lee, C. E.
    Lim, K. Y.
    Loong, L. S.
    Ponnampalavanar, S.
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 101 : 111 - 111
  • [5] Antimicrobial stewardship program implementation during the global pandemic of coronavirus disease (COVID-19)
    Martinez Suarez, Ariana
    Salamanca, Elena
    Maldonado, Natalia
    Prime Guez-Bano, Jesus Rodri
    Retamar Gentil, Pilar
    [J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACY, 2021, 43 (06) : 1737 - 1737
  • [6] A carbapenem-focused antimicrobial stewardship programme implemented during the COVID-19 pandemic in a setting of high endemicity for multidrug-resistant Gram-negative bacteria
    Spernovasilis, Nikolaos
    Kritsotakis, Evangelos, I
    Mathioudaki, Anna
    Vouidaski, Alexandra
    Spanias, Christos
    Petrodaskalaki, Maria
    Ioannou, Petros
    Chamilos, Georgios
    Kofteridis, Diamantis P.
    [J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023, 78 (04) : 1000 - 1008
  • [7] Inappropriate use of carbapenems in an internal medicine ward: Impact of a carbapenem-focused antimicrobial stewardship program
    Faraone, Antonio
    Poggi, Alice
    Cappugi, Chiara
    Tofani, Lorenzo
    Riccobono, Eleonora
    Giani, Tommaso
    Fortini, Alberto
    [J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2020, 78 : 50 - 57
  • [8] Antimicrobial stewardship implementation before and during the COVID-19 pandemic in the acute care settings: a systematic review
    Rasha Abdelsalam Elshenawy
    Nkiruka Umaru
    Amal Bandar Alharbi
    Zoe Aslanpour
    [J]. BMC Public Health, 23
  • [9] Antimicrobial stewardship implementation before and during the COVID-19 pandemic in the acute care settings: a systematic review
    Elshenawy, Rasha Abdelsalam
    Umaru, Nkiruka
    Alharbi, Amal Bandar
    Aslanpour, Zoe
    [J]. BMC PUBLIC HEALTH, 2023, 23 (01)
  • [10] Improving Antimicrobial Stewardship During the COVID-19 Pandemic
    Haddad, Mahboubeh
    Elyasi, Sepideh
    Sheybani, Fereshte
    Mireskandari, Zahra Sadat
    Morovatdar, Negar
    [J]. INFECTIOUS DISEASES IN CLINICAL PRACTICE, 2024, 32 (05)