A novel three-component coupling reaction of aryne, C = N derivatives, and acrylonitrile

被引：0

作者：

Wu, Yangang ^{[1
]}

Cai, Wenbo ^{[1
]}

Yu, Lulu ^{[1
]}

Chang, Junbiao ^{[1
]}

Song, Chuanjun ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 11卷 / 01期

关键词：

BAYLIS-HILLMAN REACTIONS; STRAIGHTFORWARD ACCESS; TERMINAL ALKYNES; ISOCYANIDES; HETEROAROMATICS; CYCLOADDITION; QUINOLINES; ANALOGS; DESIGN; IMINES;

D O I：

10.1039/d3qo01454a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A literature-unprecedented three-component aryne coupling reaction with pyrroline, imine, dihydroisoquinoline, imidazoline or oxazoline as a nucleophile, and acrylonitrile as a third component, acting as both a proton donor and a nucleophile, has been developed. With imidazoline or oxazoline as the substrate, the initially formed three-component reaction product could react further to provide tetrahydro-1,4-diazepine or tetrahydro-1,4-oxazepine, respectively.

引用

页码：89 / 93

页数：5

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