A novel three-component coupling reaction of aryne, C = N derivatives, and acrylonitrile

被引：0
|
作者：
Wu, Yangang [1 ]
Cai, Wenbo [1 ]
Yu, Lulu [1 ]
Chang, Junbiao [1 ]
Song, Chuanjun [1 ]
机构：
[1] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 11卷 / 01期
关键词：
BAYLIS-HILLMAN REACTIONS; STRAIGHTFORWARD ACCESS; TERMINAL ALKYNES; ISOCYANIDES; HETEROAROMATICS; CYCLOADDITION; QUINOLINES; ANALOGS; DESIGN; IMINES;
D O I：
10.1039/d3qo01454a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A literature-unprecedented three-component aryne coupling reaction with pyrroline, imine, dihydroisoquinoline, imidazoline or oxazoline as a nucleophile, and acrylonitrile as a third component, acting as both a proton donor and a nucleophile, has been developed. With imidazoline or oxazoline as the substrate, the initially formed three-component reaction product could react further to provide tetrahydro-1,4-diazepine or tetrahydro-1,4-oxazepine, respectively.
引用
收藏
页码：89 / 93
页数：5
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