Vitamin D deficiency and SARS-CoV-2 infection: A retrospective case-Control study with big-data analysis covering March 2020 to March 2021

被引:1
|
作者
Neira Alvarez, Marta [1 ]
Navarro Jimenez, Gema [1 ,2 ]
Anguita Sanchez, Noemi [1 ,3 ]
Bermejo Olano, Ma del Mar [2 ]
Queipo, Rocio [4 ]
Benavent Nunez, Maria [5 ]
Parralejo Jimenez, Alejandro [5 ]
Lopez Yepes, Guillermo [5 ]
Saez Nieto, Carmen [6 ]
机构
[1] Univ Europea Madrid, Infanta Sofia & Henares Hosp Fdn Biomed Res & Inn, Dept Geriatr, Madrid, Spain
[2] Infanta Sofia Univ Hosp, Infanta Sofia & Henares Hosp Fdn Biomed Res & Inn, Dept Internal Med, Madrid, Spain
[3] Zendal Hosp, Dept Geriatr, Madrid, Spain
[4] Univ Europea, Dept Med, Madrid, Spain
[5] Medsavana, Madrid, Spain
[6] Clin Univ Hosp, Dept Hosp Med, Madrid, Spain
来源
PLOS ONE | 2023年 / 18卷 / 09期
关键词
D O I
10.1371/journal.pone.0277388
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Vitamin D may have immunomodulatory functions, and might therefore play a role in the pathogenesis of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, no conclusive evidence exists regarding its impact on the prevalence of this infection, the associated course of disease, or prognosis. Objective To study the association between SARS-CoV-2 infection and vitamin D deficiency in patients attending a tertiary university hospital, and to examine the clinical course of infection and prognosis for these patients. Methods This non-interventional, retrospective study, which involved big-data analysis and employed artificial intelligence to capture data from free text in the electronic health records of patients diagnosed with SARS-CoV-2, was undertaken at a tertiary university hospital in Madrid, Spain, between March 2020 and March 2021. The variables recorded were vitamin D deficiency, sociodemographic and clinical characteristics, course of disease, and prognosis. Results Of the 143,157 patients analysed, 36,261 had SARS-CoV-2 infection (25.33%) during the study period, among whom 2,588 (7.14%) had a vitamin D deficiency. Among these latter patients, women (OR 1.45 [95%CI 1.33-1.57]), adults over 80 years of age (OR 2.63 [95%CI 2.38-2.91]), people living in nursing homes (OR 2.88 [95%CI 2.95-3.45]), and patients with walking dependence (OR 3.45 [95%CI 2.85-4.26]) appeared in higher proportion. After adjusting for confounding factors, a higher proportion of subjects with SARS-CoV-2 plus vitamin D deficiency required hospitalisation (OR 1.38 [95%CI 1.26-1.51]), and had a longer mean hospital stay (3.94 compared to 2.19 days in those with normal levels; P = 0.02). Conclusion A low serum 25(OH) vitamin D concentration in patients with SARS-CoV-2 infection is significantly associated with a greater risk of hospitalisation and a longer hospital stay. Among such patients, higher proportions of institutionalised and dependent people over 80 years of age were detected.
引用
收藏
页数:11
相关论文
共 50 条
  • [41] Risk of death in England following a positive SARS-CoV-2 test: A retrospective national cohort study (March 2020 to September 2022)
    Bauer-Staeb, Clarissa
    Holleyman, Richard James
    Barnard, Sharmani
    Hughes, Andrew
    Dunn, Samantha
    Fox, Sebastian
    Fitzpatrick, Justine
    Newton, John
    Fryers, Paul
    Burton, Paul
    Goldblatt, Peter
    PLOS ONE, 2024, 19 (10):
  • [42] Exposures associated with SARS-CoV-2 infection in France: A nationwide online case-control study
    Galmiche, Simon
    Charmet, Tiffany
    Schaeffer, Laura
    Paireau, Juliette
    Grant, Rebecca
    Cheny, Olivia
    Von Platen, Cassandre
    Maurizot, Alexandra
    Blanc, Carole
    Dinis, Annika
    Martin, Sophie
    Omar, Faiza
    David, Christophe
    Septfons, Alexandra
    Cauchemez, Simon
    Carrat, Fabrice
    Mailles, Alexandra
    Levy-Bruhl, Daniel
    Fontanet, Arnaud
    LANCET REGIONAL HEALTH-EUROPE, 2021, 7
  • [43] Community exposures among Colorado adults who tested positive for SARS-CoV-2-A case-control study, March-December 2021
    White, Alice E. E.
    Tran, Amanda D. D.
    Torok, Michelle R. R.
    Jervis, Rachel H. H.
    Albanese, Bernadette A. A.
    Buchwald, Andrea G. G.
    Schmoll, Emma
    Stringer, Ginger
    Herlihy, Rachel K. K.
    Walter, Elaine J. Scallan J.
    PLOS ONE, 2023, 18 (03):
  • [44] Splanchnic vein thrombosis associated with SARS-CoV-2 infection: A VALDIG case-control study
    Deltenre, Pierre
    Payance, Audrey
    Elkrief, Laure
    La Mura, Vincenzo
    Artru, Florent
    Baiges, Anna
    Cervoni, Jean-Paul
    China, Louise
    Colle, Isabelle
    Lemaitre, Elise
    Schiller, Dietmar
    Bureau, Christophe
    Goria, Odile
    Ollivier, Isabelle
    Nuzzo, Alexandre
    Rautou, Pierre-Emmanuel
    Plessier, Aurelie
    JHEP REPORTS, 2023, 5 (11)
  • [45] Gestational diabetes is associated with SARS-CoV-2 infection during pregnancy: A case-control study
    Radan, Anda-Petronela
    Fluri, Mihaela-Madalina
    Nirgianakis, Konstantinos
    Mosimann, Beatrice
    Schlatter, Bettina
    Raio, Luigi
    Surbek, Daniel
    DIABETES & METABOLISM, 2022, 48 (04)
  • [46] Endoplasmic Reticulum Stress Markers in SARS-COV-2 Infection and Pneumonia: Case-Control Study
    Koseler, Aylin
    Sabirli, Ramazan
    Goren, Tarik
    Turkcuer, Ibrahim
    Kurt, Ozgur
    IN VIVO, 2020, 34 : 1645 - 1650
  • [47] Association between SARS-CoV-2 infection and the physical fitness of young-adult cadets: a retrospective case-control study
    Peretz, Lidor
    Grossman, Akiva
    Saeed, Salih J.
    Appleboim-Refael, Talia
    Zloof, Yair
    Friedensohn, Limor
    Shapira, Shachar
    Shlaifer, Amir
    Grotto, Itamar
    BMJ OPEN, 2022, 12 (12):
  • [48] Case-control study of behavioural and societal risk factors for sporadic SARS-CoV-2 infections, Germany, 2020-2021 (CoViRiS study)
    Rosner, Bettina M.
    Falkenhorst, Gerhard
    Kumpf, Isabella
    Enssle, Maren
    Hicketier, Andreas
    Doerre, Achim
    Stark, Klaus
    Wilking, Hendrik
    EPIDEMIOLOGY & INFECTION, 2024, 152
  • [49] A Case-Control Study of Contextual Factors for SARS-CoV-2 Transmission
    Leite, Andreia
    Leao, Teresa
    Soares, Patricia
    Severo, Milton
    Moniz, Marta
    Lucas, Raquel
    Aguiar, Pedro
    Meireles, Paula
    Lunet, Nuno
    Nunes, Carla
    Barros, Henrique
    FRONTIERS IN PUBLIC HEALTH, 2021, 9
  • [50] First Reported Cases of SARS-CoV-2 Infection in Companion Animals - New York, March-April 2020
    Newman, Alexandra
    Smith, David
    Ghai, Ria R.
    Wallace, Ryan M.
    Torchetti, Mia Kim
    Loiacono, Christina
    Murrell, Laura S.
    Carpenter, Ann
    Motoff, Scott
    Rooney, Jane A.
    Behravesh, Casey Barton
    MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (23): : 710 - 713