Association of epidural analgesia in labor with neurodevelopmental outcomes in premature infants born at <29 weeks of gestational age

被引：0
|
作者：
Lodha, Arijit [1 ]
Moser, J. J. [2 ]
Walker, A. [2 ]
Lodha, A. [3 ]
Tang, S. [4 ,5 ]
McAllister, D. [2 ]
机构：
[1] Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada
[2] Univ Calgary, Cumming Sch Med, Dept Anesthesiol Perioperat & Pain Med, Calgary, AB, Canada
[3] Univ Calgary, Cumming Sch Med, Dept Pediat & Community Hlth Sci, Calgary, AB, Canada
[4] Dept Obstet & Gynecol, Alberta Hlth Serv, Neonatal Follow Up Clin, Calgary, AB, Canada
[5] Alberta Hlth Serv, Alberta Childrens Hosp, Neonatal Follow Up Clin, Calgary, AB, Canada
来源：
JOURNAL OF PERINATOLOGY | 2024年 / 44卷 / 04期
关键词：
NECROTIZING ENTEROCOLITIS; IMPUTATION; DISABILITY; SURVIVAL; CHILDREN;
D O I：
10.1038/s41372-024-01893-8
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To explore associations between epidural administration to mothers in labor with neurodevelopmental outcomes at 3 years corrected age in preterm infants born <29 weeks gestational age. Study design: Infants born <29 weeks gestational age between 2006 and 2012 were included. Our primary outcome was a composite of death or neurodevelopmental impairment at 3 years corrected age. Infants were divided into those whose mothers did or did not receive epidural analgesia in labor. Univariable and multivariable regression was used for analysis. Results: There were 548 infants in the no epidural analgesia group and 121 in the epidural analgesia group. The adjusted odds ratio (95%CI) of neurodevelopmental impairment or death in the epidural group was 1.25 (0.82-1.93). Propensity score-matched results were 1.32 (0.79-2.22). Conclusion: Preterm infants born <29 weeks gestational age to mothers who received epidural analgesia during labor were not associated with poor neurodevelopmental outcomes at 3 years corrected age.
引用
收藏
页码：548 / 553
页数：6
相关论文
共 50 条
  • [31] Neurodevelopmental Outcomes at 18 Months' Corrected Age of Infants Born at 22 Weeks of Gestation
    Sugiura, Tokio
    Kouwaki, Masanori
    Togawa, Yasuko
    Sugimoto, Mari
    Togawa, Takao
    Koyama, Norihisa
    NEONATOLOGY, 2011, 100 (03) : 228 - 232
  • [32] MORBIDITY AND MORTALITY IN PREMATURE-INFANTS BORN AT 23 WEEKS GESTATIONAL-AGE (GA)
    VIDWANS, A
    HUSSAIN, N
    ROWE, JC
    PEDIATRIC RESEARCH, 1995, 37 (04) : A275 - A275
  • [33] Growth of Premature Infants Born Small by Gestational Age
    Kovalenko, Tatyana
    Yuditskiy, Anton
    Petrova, Irina
    HORMONE RESEARCH IN PAEDIATRICS, 2018, 90 : 384 - 385
  • [34] Survival and long-term neurodevelopmental outcome of extremely premature infants born at 23-26 weeks' gestational age at a tertiary center
    Hoekstra, RE
    Ferrara, TB
    Couser, RJ
    Payne, NR
    Connett, JE
    PEDIATRICS, 2004, 113 (01) : E1 - E6
  • [35] Morbidity and mortality among appropriate for gestational age (AGA) infants born &lt;32 weeks of gestation
    Vuerich, M
    Kovacs, LB
    Pelausa, E
    Papageorgiou, A
    PEDIATRIC RESEARCH, 2004, 55 (04) : 380A - 380A
  • [36] Actuarial Survival Based on Gestational Age in Days at Birth for Infants Born at &lt;26 Weeks of Gestation
    Shah, Prakesh S.
    Rau, Sanaya
    Yoon, Eugene W.
    Alvaro, Ruben
    Silva, Orlando
    Makary, Hala
    Claveau, Martine
    Lee, Shoo K.
    JOURNAL OF PEDIATRICS, 2020, 225 : 97 - +
  • [37] The influence of birthweight for gestational age on neurodevelopmental outcome at 1 year of age in premature infants weighing &lt; 1000 g
    Lloyd, J.
    Riley, K.
    Wyatt, J.
    Peebles, D.
    EARLY HUMAN DEVELOPMENT, 2006, 82 (09) : 616 - 617
  • [38] Long-Term Neurodevelopmental and Growth Outcomes of Premature Infants Born at <29 week Gestational Age with Post-Hemorrhagic Hydrocephalus Treated with Ventriculo-Peritoneal Shunt
    K. Diwakar
    Walter J. Hader
    A. Soraisham
    Harish Amin
    Selphee Tang
    Kelly Bullivant
    Majeeda Kamaluddeen
    Abhay Lodha
    The Indian Journal of Pediatrics, 2017, 84 : 662 - 669
  • [39] Neurodevelopmental outcomes of preterm small for gestational age infants born to mothers with and without preeclampsia.
    Rogers, EE
    Leonard, C
    Piecuch, R
    JOURNAL OF INVESTIGATIVE MEDICINE, 2006, 54 (01) : S174 - S174
  • [40] NEURODEVELOPMENTAL OUTCOME AT 18 MONTHS OF CORRECTED AGE FOR LATE PRETERM INFANTS BORN AT 34 AND 35 GESTATIONAL WEEKS
    Nakasone, R.
    Fujioka, K.
    Iijima, K.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2021, 69 (01) : 167 - 167
12345