Reductive Deuteration of Acyl Chlorides for the Synthesis of a,a-Dideuterio Alcohols Using SmI2 and D2O

被引：1

作者：

Li, Hengzhao ^{[1
,2
,3
]}

Hou, Yuxia ^{[2
,3
]}

Peng, Mengqi ^{[1
,2
,3
]}

Wang, Lijun ^{[1
,2
,3
]}

Li, Junyu ^{[1
]}

Ning, Lei ^{[1
]}

Lai, Zemin ^{[1
]}

Li, Yixuan ^{[1
]}

An, Jie ^{[1
]}

机构：

[1] China Agr Univ, Dept Nutr & Hlth, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China

[2] China Agr Univ, Dept Chem, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China

[3] China Agr Univ, Innovat Ctr Pesticide Res, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 01期

基金：

中国国家自然科学基金;

关键词：

acyl chlorides; reductive deuteration; a; a-dideuterio alcohols; SmI2; D2O; ALPHA; ALPHA-DIDEUTERIO ALCOHOLS; SELECTIVE SYNTHESIS; DEUTERIUM; ACIDS; PRECURSORS; PESTICIDES; ESTERS;

D O I：

10.3390/molecules28010416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of alpha,alpha-dideuterio alcohols has been achieved via single electron transfer reductive deuteration of acyl chlorides using SmI2 and D2O. This method is distinguished by its remarkable functional group tolerance and exquisite deuterium incorporation, which has also been applied to the synthesis of valuable deuterated agrochemicals and their building blocks.

引用

页数：10

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