Functional Imaging of Chemobrain: Usefulness of Nuclear Medicine in the Fog Coming After Cancer

被引：2

作者：

Chiaravalloti, Agostino ^{[1
,2
]}

Filippi, Luca ^{[3
]}

Pagani, Marco ^{[4
,5
]}

Schillaci, Orazio ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy

[2] IRCCS Neuromed, Pozzilli, Italy

[3] Santa Maria Goretti Hosp, Nucl Med Sect, Latina, Italy

[4] CNR, Inst Cognit Sci & Technol, Rome, Italy

[5] Karolinska Hosp, Dept Med Radiat Phys & Nucl Med, Stockholm, Sweden

来源：

JOURNAL OF NUCLEAR MEDICINE | 2023年 / 64卷 / 04期

关键词：

Key Words; chemobrain; functional imaging; PET; FDG; DAT; neuroinflammation; COGNITIVE IMPAIRMENT; BREAST-CANCER; HODGKINS-LYMPHOMA; BRAIN METABOLISM; CHEMOTHERAPY; PET; HYPOMETABOLISM; NEUROTOXICITY; DYSFUNCTION; TOMOGRAPHY;

D O I：

10.2967/jnumed.121.263294

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The impact of chemotherapy on brain functionality has been widely investigated from a clinical perspective, and there is a consensus on a significant impairment of multiple cognitive domains affecting cancer patients after treatment. Nuclear medicine offers a variety of biomar-kers for evaluating possible effects of chemotherapy on the brain and for depicting brain changes after chemotherapy. This review sum-marizes the most relevant findings on brain imaging in patients undergoing chemotherapy for the most common oncologic diseases. The literature published to date offers exciting results on several radi-olabeled compounds, from the more common imaging of glucose metabolism to neuroinflammation. This review also provides a general overview of the literature concerning clinical features and the physio-pathologic basis of chemotherapy-related cognitive impairment.

引用

页码：508 / 514

页数：7

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