Functional Imaging of Chemobrain: Usefulness of Nuclear Medicine in the Fog Coming After Cancer

被引：2
|
作者：
Chiaravalloti, Agostino [1 ,2 ]
Filippi, Luca [3 ]
Pagani, Marco [4 ,5 ]
Schillaci, Orazio [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy
[2] IRCCS Neuromed, Pozzilli, Italy
[3] Santa Maria Goretti Hosp, Nucl Med Sect, Latina, Italy
[4] CNR, Inst Cognit Sci & Technol, Rome, Italy
[5] Karolinska Hosp, Dept Med Radiat Phys & Nucl Med, Stockholm, Sweden
来源：
JOURNAL OF NUCLEAR MEDICINE | 2023年 / 64卷 / 04期
关键词：
Key Words; chemobrain; functional imaging; PET; FDG; DAT; neuroinflammation; COGNITIVE IMPAIRMENT; BREAST-CANCER; HODGKINS-LYMPHOMA; BRAIN METABOLISM; CHEMOTHERAPY; PET; HYPOMETABOLISM; NEUROTOXICITY; DYSFUNCTION; TOMOGRAPHY;
D O I：
10.2967/jnumed.121.263294
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The impact of chemotherapy on brain functionality has been widely investigated from a clinical perspective, and there is a consensus on a significant impairment of multiple cognitive domains affecting cancer patients after treatment. Nuclear medicine offers a variety of biomar-kers for evaluating possible effects of chemotherapy on the brain and for depicting brain changes after chemotherapy. This review sum-marizes the most relevant findings on brain imaging in patients undergoing chemotherapy for the most common oncologic diseases. The literature published to date offers exciting results on several radi-olabeled compounds, from the more common imaging of glucose metabolism to neuroinflammation. This review also provides a general overview of the literature concerning clinical features and the physio-pathologic basis of chemotherapy-related cognitive impairment.
引用
收藏
页码：508 / 514
页数：7
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