Contribution of microvascular dysfunction to chronic pain

被引：3
|
作者：
Coderre, Terence J. [1 ,2 ]
机构：
[1] McGill Univ, Dept Anesthesia, Montreal, PQ, Canada
[2] McGill Univ, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada
来源：
FRONTIERS IN PAIN RESEARCH | 2023年 / 4卷
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
endothelial cells; microvascular injury; ischemia-reperfusion; oxidative stress; antioxidants; cytokines; REFLEX SYMPATHETIC DYSTROPHY; SYNDROME TYPE-I; SKELETAL-MUSCLE; FIBROMYALGIA SYNDROME; NITRIC-OXIDE; BLOOD-FLOW; PATHOLOGY; SKIN; ANTIOXIDANTS; MICROCIRCULATION;
D O I：
10.3389/fpain.2023.1111559
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
There is growing evidence that microvascular dysfunction is a pathology accompanying various injuries and conditions that produce chronic pain and may represent a significant contributing factor. Dysfunction that occurs within each component of the microvasculature, including arterioles, capillaries and venules impacts the health of surrounding tissue and produces pathology that can both initiate pain and influence pain sensitivity. This mini review will discuss evidence for a critical role of microvascular dysfunction or injury in pathologies that contribute to chronic pain conditions such as complex regional pain syndrome (CRPS) and fibromyalgia.
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页数：5
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