Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy

被引：7
|
作者：
Gao, Jiake [1 ]
Jiang, Hongfei [1 ]
Chen, Pengwei [2 ]
Zhang, Renshuai [1 ]
Liu, Ning [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China
[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China
来源：
BIOORGANIC CHEMISTRY | 2023年 / 136卷
关键词：
Theranostic; Photosensitizer; Phototherapy; Tumor -targeted imaging; Drug design; PHOTODYNAMIC THERAPY; CELL-DEATH; CANCER; ACTIVATION; ABLATION; PROBE; FLUOROPHORES; FLUORESCENCE; SENSITIZER; GROWTH;
D O I：
10.1016/j.bioorg.2023.106554
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Small molecule theranostic agents for tumor treatment exhibited triadic properties in tumor targeting, imaging, and therapy, which have attracted increasing attention as a potential complement for, or improved to, classical small molecule antitumor drugs. Photosensitizer have dual functions of imaging and phototherapy, and have been widely used in the construction of small molecule theranostic agents over the last decade. In this review, we summarized representative agents that have been studied in the field of small molecule theranostic agents based on photosensitizer in the last decade, and highlighted their characteristics and application in tumor-targeted monitoring and phototherapy. The challenges and future perspectives of photosensitizers in building small molecule theranostic agents for diagnosis and therapy of tumors were also discussed.
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收藏
页数：15
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