Synthesis of New Thiazolidinones and Thiazoles in Indole Series

被引：3

作者：

Khanoussi, Sofiane ^{[1
]}

Benmohammed, Abdelmadjid ^{[1
,2
]}

Khoumeri, Omar ^{[3
]}

Kadiri, Mokhtaria ^{[1
]}

Djafri, Ayada ^{[1
]}

Terme, Thierry ^{[3
]}

Vanelle, Patrice ^{[3
]}

机构：

[1] Univ Oran1 Ahmed Ben Bella, Fac Sci Exactes & Appl, Dept Chim, Lab Synth Organ Appliquee LSOA, BP 1524 MNaouer, Oran 31000, Algeria

[2] Univ Mascara, Fac Exact Sci, Dept Chem, Mascara 29000, Algeria

[3] Aix Marseille Univ, ICR Inst Chim Radicalaire, Fac Pharm, Lab Pharmaco Chim Radicalaire,CNRS,UMR 7273, 27 Blvd Jean Moulin, F-13385 Marseille 05, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2023年 / 20卷 / 01期

关键词：

Thiosemicarbazone; thiazolidinone; thiazole; indole; condensation; cyclization; BIOLOGICAL EVALUATION; THIOSEMICARBAZONE DERIVATIVES; AGENTS; ANTIOXIDANT; ANTICONVULSANT; COMPLEXES; DOCKING; DESIGN;

D O I：

10.2174/1570178619666220827152700

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Recent findings confirm that thiosemicarbazones and thiazoles offer a wide range of biological properties. We report here the synthesis of two series of highly functionalized thiazole-derived compounds from the reactions of various indole-derived thiosemicarbazones with diethyl acetylenedicarboxylate and 4-bromophenacyl bromide. As a result, a series of new derivatives of thiosemicarbazone, thiazolidinone, and thiazole bearing an indole moiety was synthesized and developed in good yields.

引用

页码：11 / 17

页数：7

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