The role of TLR4-mediated MyD88/TRAF6/NF-KB signaling and pIgR intestinal expression in chicks during Salmonella enteritidis infection

被引：4
|
作者：
Zhang, C. [1 ]
Ding, Y. [1 ]
Liu, Y. F. [1 ,2 ]
Wang, H. B. [1 ,2 ]
Wang, X. J. [1 ]
Wang, S. Y. [1 ]
Sun, Z. Y. [3 ]
Li, D. J. [1 ,2 ]
机构：
[1] Northeast Agr Univ, Dept Vet Med, Harbin 150030, Peoples R China
[2] Key Lab Prov Educ Dept Heilongjiang Common Anim Di, Beijing, Peoples R China
[3] Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, Guangzhou 510225, Peoples R China
来源：
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2023年 / 258卷
关键词：
TLR4; signaling; pIgR; chick; Salmonellaenteritidis; TOLL-LIKE RECEPTORS; POLYMERIC IMMUNOGLOBULIN RECEPTOR; TLR4; LIPOPOLYSACCHARIDE; RNA;
D O I：
10.1016/j.vetimm.2023.110563
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To observe the effect of Salmonella enteritidis (SE)-induced inflammation on pIgR expression in jejunum and ileum. Salmonella enteritidis was orally administered to 7-day old Hyline chicks, which were killed after 1d,3d,7d and 14d. The mRNA expression of TLR4,MyD88,TRAF6,NF-KB, and pIgR was detected by real-time RT-PCR, and pIgR protein was detected by Western blotting. The TLR4 signaling pathway was activated, the mRNA expression of the pIgR in jejunum and ileum was increased, and pIgR protein in jejunum and ileum was up-regulated by SE. In SE-treated chicks,the pIgR in jejunum and ileum was up-regulated on mRNA,and protein level,associated with activation of the TRL4-mediated MyD88/TRAF6/NF-KB signaling pathway, which identifies this as a novel pIgR-related pathway to TLR4 activation.
引用
收藏
页数：6
相关论文
共 40 条
  • [1] MyD88 Adapter-like (Mal)/TIRAP Interaction with TRAF6 Is Critical for TLR2-and TLR4-mediated NF-κB Proinflammatory Responses
    Verstak, Brett
    Nagpal, Kamalpreet
    Bottomley, Stephen P.
    Golenbock, Douglas T.
    Hertzog, Paul J.
    Mansell, Ashley
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (36) : 24192 - 24203
  • [2] Nano-selenium supplementation upregulate TLR-7, MyD88, NF-kB, and TRAF6 genes in thymus of Wistar rats following treatment with cyclosporine A
    Rezvani, Nafiseh
    Shirvani, Hossein
    Rostamkhani, Fatemeh
    NANOMEDICINE JOURNAL, 2024, 11 (02) : 137 - 144
  • [3] Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-kB signaling pathway in diabetic rats
    Li, Jianping
    Liu, Xia
    Wu, Yuzhen
    Ji, Wei
    Tian, Qinghua
    Li, Shichen
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 634 : 75 - 82
  • [4] Xiaoer niuhuang qingxin powder alleviates influenza a virus infection by inhibiting the activation of the TLR4/MyD88/NF-KB signaling pathway
    Ma, Lanying
    Wang, Tong
    Liu, Meiyi
    Ji, Lingyun
    Wang, Yanan
    Li, Shuting
    Zhang, Yanan
    Wang, Yuan
    Zhao, Wenxiao
    Wu, Zhichun
    Yu, Huayun
    Zhao, Haijun
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 328
  • [5] Fuzi-Lizhong Decoction Alleviates Nonalcoholic Fatty Liver Disease by Blocking TLR4/MyD88/TRAF6 Signaling
    Yang, Jiayao
    Zhang, Ying
    Yi, Hongfeng
    Liao, Yan
    Shu, Lei
    Zhang, Shu
    Li, Chenyu
    An, Liu
    Du, Nianlong
    Shi, Zhaohong
    Ma, Wei
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [6] Ragweed Pollen Proteins Bind TLR4/MD2, and Rapidly Recruit MyD88 and TRAF6 To The Signaling Complex
    Sun, Qian
    Hosoki, Koa
    Aguilera-Aguirre, Leopoldo
    Boldogh, Istvan
    Sur, Sanjiv
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (02) : AB225 - AB225
  • [7] Inhibition of MyD88 signaling or NF-kB activation by pyrrolidine dithiocarbamate (PDTC) reduces SOCS3 expression during sepsis
    Chung, CS
    Grutkoski, P
    Chen, Y
    Ayala, A
    FASEB JOURNAL, 2004, 18 (04): : A433 - A433
  • [8] A promoting role for the epithelial MyD88/IRAK4/NF-kB signaling in K-ras mutant lung tumorigenesis
    Castro, Susana
    Daliri, Soudabeh
    De La Garza, Maria Miguelina
    Cumpian, Amber M.
    Umer, Misha
    Del Bosque, Diana
    Akbani, Sabah
    Evans, Scott E.
    Moghaddam, Seyed Javad
    CANCER RESEARCH, 2017, 77
  • [9] Sevoflurane postconditioning ameliorates cerebral ischemia-reperfusion injury in rats via TLR4/MyD88/TRAF6 signaling pathway
    Zhao, Zijun
    Li, Yishuai
    Chi, Fei
    Ma, Li
    Li, Yanan
    Hou, Zhiyong
    Wang, Qiujun
    AGING-US, 2022, 14 (24): : 10153 - 10170
  • [10] Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway
    He, Jinyue
    He, Zhuoen
    Wang, Hao
    Zhang, Chi
    Pei, Tingting
    Yan, Shihua
    Yan, Yangtian
    Wang, Fujing
    Chen, Yuchi
    Yuan, Ningning
    Wang, Mingqing
    Xiao, Wei
    BIOMEDICINE & PHARMACOTHERAPY, 2024, 174
1234