Exercise-induced Brain-derived neurotrophic factor regulation in the brain dysfunctions

Objectives. - This review explains how exercise can prevent the neurodegeneration and addresses the important role of Brain-derived neurotrophic factor as an indicator of symptoms of ageing brain dysfunction. In addition, it explains the cellular and molecular mechanisms of exercise on regulation of Brain-derived neurotrophic factor in brain, that it's dysregulation appears in many pathological conditions. News. - It is known that mitochondrial dysfunctions associated with upregulation of reactive oxygen species, has vital role in various neurodegenerative disorder. Neurotrophins factor have numerous beneficial effects on neuroplasticity and neurosurvival and the goal of many drug therapies is to increase neurotrophins. Prospects and projects. - Unfortunately, pharmacological methods are time consuming and costly, and, after a while drug resistance develops. Exercise as an adjunct intervention has promising results but various factors affect the results that should be carefully investigated in the studies. Exercise can increase brain mitochondrial biogenesis and attenuates effects of the ageing process on the brain. Regulation of Brain-derived neurotrophic factor by exercise is related to antidepressant effects and enhance of cognitive function and mitochondrial capacity that negates the ageing dysfunctions. Conclusion. - The mechanisms of exercise-induced adaptations in neurodegenerative dysfunctions remain undiscovered and assesses the effect of exercise on neurodysfunction hasencountered many difficulties. Therefore, further studies are needed to resolve existing inconsistencies. However, there is a positive relationship between regular exercise and Brain-derived neurotrophic factor regulation, which can prevent or reduce symptoms of brain diseases, especially in ageing. (c) 2023 Elsevier Masson SAS. All rights reserved.