Difficult-to-treat rheumatoid arthritis treated with Abatacept combined with Baricitinib: A case report

被引：0
|
作者：
Qi, Jia-Ping [1 ,2 ,3 ]
Jiang, Huan [2 ,3 ,4 ]
Wu, Teng [2 ,3 ,4 ]
Zhang, Yuan [1 ,2 ,3 ]
Huang, Wei [2 ,3 ]
Li, Yi-Xuan [2 ,3 ,4 ]
Wang, Jing [2 ,3 ,4 ]
Zhang, Ju [2 ,3 ]
Ying, Zhen-Hua [1 ,2 ,3 ,4 ]
机构：
[1] Bengbu Med Coll, Grad Sch, Bengbu 233030, Anhui, Peoples R China
[2] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Ctr Gen Practice Med, Dept Rheumatol & Immunol, 158 Shangtang Rd, Hangzhou 310000, Zhejiang, Peoples R China
[3] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Zhejiang Prov Key Lab Tradit Chinese Med Cultivat, Hangzhou 310000, Zhejiang, Peoples R China
[4] Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310000, Zhejiang, Peoples R China
来源：
WORLD JOURNAL OF CLINICAL CASES | 2023年 / 11卷 / 11期
关键词：
Difficult-to-treat rheumatoid arthritis; Abatacept; Baricitinib; Combination therapy; Case report; INHIBITORS; JAK;
D O I：
10.12998/wjcc.v11.i11.2474
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BACKGROUNDSporadic cases of rheumatoid arthritis (RA) due to unsatisfactory responses to Abatacept (ABT) have been reported; however, the rescue therapy has not been finalized. Here, we present a case with difficult-to-treat RA (D2T RA) that was resistant to either a single ABT or a Janus kinase (JAK) inhibitor (Tofacitinib), but improved with a combination of ABT and JAK inhibitor (Baricitinib, BAT).CASE SUMMARYA 46-year-old Chinese woman who had RA for ten years that was resistant to Tocilizumab, Etanercept, Adalimumab, and ABT. According to the European League Against Rheumatism definition, the patient was diagnosed with D2T RA. It was then improved with a combination of ABT and a JAK inhibitor BAT.CONCLUSIONABT combined with BAT may be an acceptable strategy for treating D2T RA.
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页数：9
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