Folic acid: friend or foe in cancer therapy

被引：5

作者：

Thabet, Romany H. ^{[1
,2
,5
]}

Alessa, Raneem Eid Mustafa ^{[3
]}

Al-Smadi, Zahraa Khaldoon Khaleel ^{[3
]}

Alshatnawi, Banah Saleh Gabr ^{[3
]}

Amayreh, Batool Mahmoud Ibrahim ^{[3
]}

Al-Dwaaghreh, Renad Bilal Ahmad ^{[3
]}

Salah, Sereen Khalid Ahmad ^{[4
]}

机构：

[1] Assiut Univ, Fac Med, Dept Pharmacol, Assiut, Egypt

[2] Aqaba Med Sci Univ, Fac Med, Dept Basic Med Sci, Aqaba, Jordan

[3] Yarmouk Univ, Fac Med, Dept Basic Med Sci, Irbid, Jordan

[4] Princess Basma Hosp, Minist Hlth, Irbid, Jordan

[5] Aqaba Med Sci Univ, Fac Med, Dept Basic Med Sci, C12 Al Haddab,Parallel Rd,South Beach, Aqaba 77110, Jordan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2024年 / 52卷 / 01期

关键词：

Breast cancer; carcinogenic; colorectal cancer; folate; folic acid; lung cancer; prostate cancer; NEURAL-TUBE DEFECTS; DIETARY-FOLATE INTAKE; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; ACUTE LYMPHOBLASTIC-LEUKEMIA; ONE-CARBON METABOLISM; PROSTATE-CANCER; FOOD FORTIFICATION; COLORECTAL-CANCER; PANCREATIC-CANCER; COLON-CANCER;

D O I：

10.1177/03000605231223064

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Folic acid plays a crucial role in diverse biological processes, notably cell maturation and proliferation. Here, we performed a literature review using articles listed in electronic databases, such as PubMed, Scopus, MEDLINE, and Google Scholar. In this review article, we describe contradictory data regarding the role of folic acid in cancer development and progression. While some studies have confirmed its beneficial effects in diminishing the risk of various cancers, others have reported a potential carcinogenic effect. The current narrative review elucidates these conflicting data by highlighting the possible molecular mechanisms explaining each point of view. Further multicenter molecular and genetic studies, in addition to human randomized clinical trials, are necessary to provide a more comprehensive understanding of the relationship between folic acid and cancer.

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页数：19

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