The Roles of miRNAs in Predicting Bladder Cancer Recurrence and Resistance to Treatment

被引：7

作者：

Das, Sanjna ^{[1
]}

Hayden, Joshua ^{[2
]}

Sullivan, Travis ^{[1
]}

Rieger-Christ, Kimberly ^{[1
]}

机构：

[1] Lahey Hosp & Med Ctr, Dept Translat Res, Burlington, MA 01805 USA

[2] Lahey Hosp & Med Ctr, Dept Urol, Burlington, MA 01805 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 02期

关键词：

bladder cancer (BCa); recurrence; chemoresistance; miRNA; EMT; cell cycle; fatty acid metabolism; Wnt; HIPPO; FGFR3; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION SIGNATURES; MULTI-CHEMORESISTANCE; DOWN-REGULATION; CISPLATIN-RESISTANCE; CELL-PROLIFERATION; SIGNALING PATHWAY; NONINVASIVE BIOMARKERS; WNT/BETA-CATENIN; FGFR3; EXPRESSION;

D O I：

10.3390/ijms24020964

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bladder cancer (BCa) is associated with significant morbidity, with development linked to environmental, lifestyle, and genetic causes. Recurrence presents a significant issue and is managed in the clinical setting with intravesical chemotherapy or immunotherapy. In order to address challenges such as a limited supply of BCG and identifying cases likely to recur, it would be advantageous to use molecular biomarkers to determine likelihood of recurrence and treatment response. Here, we review microRNAs (miRNAs) that have shown promise as predictors of BCa recurrence. MiRNAs are also discussed in the context of predicting resistance or susceptibility to BCa treatment.

引用

页数：17

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