Synthesis of the C13-C27 Fragment of Madeirolide A Using Visible-Light-Promoted Radical Cyclization

被引：0

作者：

Hwang, Sunghyun ^{[1
]}

Choi, Minchul ^{[1
]}

Jeong, Myungeun ^{[1
]}

Lee, Chulbom ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 08826, South Korea

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

NI(II)/CR(II)-MEDIATED COUPLING REACTION; ENANTIOSELECTIVE TOTAL-SYNTHESIS; ESTERS; TRANSFORMATIONS; MANDELALIDE; MACROLIDES; ACCESS;

D O I：

10.1021/acs.orglett.3c04305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The convergent synthesis of a fully elaborated C13-C27 fragment of madeirolide A has been achieved. The key features of the synthesis include the stereocontrolled construction of both the THF and THP rings via visible-light-induced iridium-catalyzed radical cyclization and the late-stage union of the two oxacyclic subunits through nickel-catalyzed decarboxylative cross-coupling.

引用

页码：1067 / 1072

页数：6

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