Research Progress on Pyroptosis in Hematological Malignancies

被引：2
|
作者：
Lyu, Tianxin
Yin, Qingsong [1 ]
机构：
[1] Zhengzhou Univ, Dept Hematol, Affiliated Canc Hosp, Zhengzhou 450008, Peoples R China
来源：
CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2023年 / 24卷 / 10期
关键词：
Hematological malignancies; Pyroptosis; Caspase pathway; GASDERMIN D; MYC; QUADRUPLEX; INHIBITION; DEATH;
D O I：
10.1007/s11864-023-01119-7
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pyroptosis is a kind of programmed cell death dependent on the caspase pathway that is different from apoptosis and necrosis. Recent studies have shown that pyroptosis can be involved in the pathological processes of many diseases, such as cancers, atherosclerosis, diabetic nephropathy, and blood diseases. However, the specific mechanisms by which pyroptosis participates in the occurrence and development of hematological malignant tumors still need further exploration. This article reviews the characteristics of pyroptosis and the regulatory mechanisms promoting or inhibiting pyroptosis and discusses the role of pyroptosis in hematological malignant tumors, which could provide ideas for the clinical treatment of such tumors in the future.
引用
收藏
页码：1439 / 1450
页数：12
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