Vector Biodistribution and Transgene Expression in the Heart Following Gene Transfer of AAVrh.10 vs. AAV9 Capsids

被引：0
|
作者：
Selvan, Nithya [1 ]
Nair, Anju [1 ]
Fargnoli, Anthony S. [1 ]
Zhang, Jing [2 ]
Wang, Jie [2 ]
Bradford, William H. [2 ]
Granados, Sonia Gutierrez [1 ]
Law, Kenneth M. [1 ]
Fenn, Tim [1 ]
McCormac, Paul [1 ]
Barth, Jay [1 ]
Sheikh, Farah [2 ]
Khanna, Richie [1 ]
机构：
[1] Lexeo Therapeut, New York, NY USA
[2] Univ Calif San Diego, San Diego, CA USA
来源：
MOLECULAR THERAPY | 2023年 / 31卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
1241
引用
收藏
页码：590 / 590
页数：1
相关论文
共 50 条
  • [1] AAV9, AAVrh.10, and AAVrh.74 Exhibit Different Cell Type Tropisms in the Heart Following Systemic Delivery and AAV9 Mediates Superior Cardiomyocyte Transgene Expression in Murine and Non-Human Primate Models
    Cheng, Ze
    Easter, Emilee
    Rollosson, Lindsey M.
    Xu, Emma
    Zhou, Huanyu
    Doerner, Karl
    Lin, JianMin
    Ivey, Kathryn N.
    Hoey, Timothy
    Lombardi, Laura M.
    MOLECULAR THERAPY, 2024, 32 (04) : 250 - 250
  • [2] Improved heart specific gene transfer of AAV9 vectors with microRNA regulated transgene expression
    Geisler, Anja
    Jungmann, Andreas
    Vetter, Roland
    Muller, Oliver
    Fechner, Henry
    HUMAN GENE THERAPY, 2009, 20 (11) : 1381 - 1381
  • [3] Evaluation of AAV9 and AAVrh.10 mCherry Vectors in Adult Cynomolgus Macaques after Intracisterna Magna Administration
    Shen, Shen
    Grubor, Branka
    Plowey, Edward
    Clarner, Pete
    Nambiar, Kalyani
    Kirkland, Melissa
    Hamann, Stefan
    Trapa, Patrick
    Tien, Eric
    Morris, Dale
    Suh, Junghae
    MOLECULAR THERAPY, 2021, 29 (04) : 168 - 169
  • [4] Systemic AAVrh10 provides higher transgene expression than AAV9 in the brain and the spinal cord of neonatal mice
    Tanguy, Yannick
    Biferi, Maria G.
    Besse, Aurore
    Astord, Stephanie
    Cohen-Tannoudji, Mathilde
    Marais, Thibaut
    Barkats, Martine
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2015, 8
  • [5] Comparison of U7snRNA-induced dystrophin expression following systemic delivery with AAV9 and AAVrh74 capsids
    Lay, J.
    Frair, E.
    Bradley, A.
    Vetter, T.
    Rohan, N.
    Bellinger, C.
    Waldrop, M.
    Wein, N.
    Gushchina, L.
    Flanigan, K.
    NEUROMUSCULAR DISORDERS, 2023, 33 : S100 - S100
  • [6] Immune Activation and Transgene Stability Following AAV9 Gene Transfer to an Acute Myocardial Infarct Mouse Model
    Faust, Susan
    Gao, Ehre
    Tenney, Rebecca
    Ohlstein, Jason
    Bell, Peter
    Koch, Walter
    Wilson, James
    Rabinowitz, Joseph
    MOLECULAR THERAPY, 2013, 21 : S171 - S172
  • [7] Cardiac Toxicity of AAV9 Vector Upon Heart-Specific Expression of an Immunogenic Non-Self Transgene
    Park, Andrew
    Urakami, Akane
    Alfaro, Alex
    Wu, Herren
    Ikeda, Yasuhiro
    MOLECULAR THERAPY, 2020, 28 (04) : 47 - 47
  • [8] Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart
    Qiao, Chunping
    Yuan, Zhenhua
    Li, Jianbin
    Tang, Ruhang
    Li, Juan
    Xiao, Xiao
    HUMAN GENE THERAPY METHODS, 2012, 23 (01) : 29 - 37
  • [9] Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector
    Karan, Kalpita R.
    Andrzejewski, Slawomir
    Stiles, Katie M.
    Hackett, Neil R.
    Crystal, Ronald G.
    HUMAN GENE THERAPY, 2024, 35 (21-22) : 904 - 916
  • [10] Gene delivery and biodistribution following intravenous administration of AAV9/rh10 iduronidase in a murine model of MPS type I
    Belur, Lalitha
    Thuy An Tran
    Podetz-Pedersen, Kelly M.
    Riedl, Maureen
    Vulchanova, Lucy
    Kozarsky, Karen
    Low, Walter C.
    McIvor, R. Scott
    MOLECULAR GENETICS AND METABOLISM, 2016, 117 (02) : S26 - S26
12345