Novel 5,6,7,8-tetrahydrobenzo[b]pyran Derivatives: Synthesis and Anticancer Activity

被引：1

作者：

Abdallah, Amira E. M. ^{[1
]}

Mohareb, Rafat M. ^{[2
]}

Helal, Maher H. E. ^{[1
]}

Abd Elkader, Mariam M. ^{[1
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Chem, Cairo 11795, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza 12614, Egypt

来源：

ACTA CHIMICA SLOVENICA | 2023年 / 70卷 / 02期

关键词：

Tetrahydrobenzo[b]pyran; thiophene; pyridine; anti-proliferative activity; ONE-POT SYNTHESIS; EFFICIENT; THIOPHENE; ACID;

D O I：

10.17344/acsi.2022.7893

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Many new cyclized pyran systems with a potential anti-cancer activity were designed and prepared. Pyran systems showed high reactivity to various chemical reagents. 24 products of the prepared compounds were chosen and tested in (mM) as respectable anticancer factors. The findings revealed that compounds 3b, 6b, and 8 were the widely effective compounds against the three cancer cell lines including A-549 (lung carcinoma), HC-29 (colorectal adenocarcinoma), and MKN-45 (gastric cancer) compared to the standard reference control foretinib.

引用

页码：261 / 273

页数：13

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