Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

被引：8
|
作者：
Cui, Qiaozhen [1 ]
Wang, Chen [2 ]
Wang, Qichen [2 ]
Qin, Juanxiu [2 ]
Li, Min [2 ]
Ding, Baixing [3 ,4 ,6 ]
Shen, Zhen [2 ,5 ]
机构：
[1] Shanxi Bethune Hosp, Taiyuan, Peoples R China
[2] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai, Peoples R China
[3] Fudan Univ, Shanghai Minist Hlth, Huashan Hosp, Shanghai, Peoples R China
[4] Minist Hlth, Key Lab Clin Pharmacol Antibiot, Shanghai, Peoples R China
[5] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Lab Med, 160 Pujian Rd, Shanghai, Peoples R China
[6] Fudan Univ, Huashan Hosp, Inst Antibiot, 12 Wulumuqi Rd, Shanghai, Peoples R China
来源：
EMERGING INFECTIOUS DISEASES | 2023年 / 29卷 / 11期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.3201/eid2911.230830
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for blaSHV-12, leading to blaSHV-12 overexpression and ment contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.
引用
收藏
页码：2398 / 2400
页数：3
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